FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2067291571> ?p ?o ?g. }

• W2067291571 endingPage "72" @default.
• W2067291571 startingPage "59" @default.
• W2067291571 abstract "Tooth root supports dental crown and bears occlusal force. While proper root shape and size render the force being evenly delivered and dispersed into jawbone. Yet it remains unclear what shape and size of a biological tooth root (bio-root), which is mostly determined by the scaffold geometric design, is suitable for stress distributing and mastication performing. Therefore, this study hypothesized scaffold fabricated in proper shape and size is better for regeneration of tooth root with approving biomechanical functional features. In this study, we optimized shape and size of scaffolds for bio-root regeneration using computer aided design (CAD) modeling and finite element analysis (FEA). Statical structural analysis showed the total deformation (TD) and equivalent von-mises stress (EQV) of the restored tooth model mainly concentrated on the scaffold and the post, in accordance with the condition in a natural post restored tooth. Design sensitivity analysis showed increasing the height and upper diameter of the scaffold can tremendously reduce the TD and EQV of the model, while increasing the bottom diameter of scaffold can, to some extent, reduce the EQV in post. However, increase on post height had little influence on the whole model, only slightly increased the native EQV stress in post. Through response surface based optimization, we successfully screened out the optimal shape of the scaffold used in tissue engineering of tooth root. The optimal scaffold adopted a slightly tapered shape with the upper diameter of 4.9 mm, bottom diameter of 3.4 mm; the length of the optimized scaffold shape was 9.4 mm. While the analysis also suggested a height of about 9 mm for a metal post with a diameter of 1.4 mm suitable for crown restoration in bio-root regeneration. In order to validate the physiological function of the shape optimized scaffold in vivo, we transplanted the shape optimized treated dentin matrix (TDM) scaffold, seeding with dental stem cells, into alveolar bone of swine and further installed porcelain crown. Results showed that tooth root has not only been successfully regenerated histologically but also performed masticatory function and maintained stable for three months after crown restoration. Our results suggested that TDM scaffold with 9.4 mm in length and 4.9 mm/3.4 mm in upper/bottom diameter is a suitable biological scaffold for tooth root regeneration. These results also provided a recommendable design protocol for fabricating other scaffolds in tooth root reconstruction." @default.
• W2067291571 created "2016-06-24" @default.
• W2067291571 creator A5005793057 @default.
• W2067291571 creator A5019385672 @default.
• W2067291571 creator A5026143070 @default.
• W2067291571 creator A5042006674 @default.
• W2067291571 creator A5045067652 @default.
• W2067291571 creator A5046972210 @default.
• W2067291571 creator A5048868468 @default.
• W2067291571 creator A5054610344 @default.
• W2067291571 creator A5065859286 @default.
• W2067291571 creator A5076347170 @default.
• W2067291571 date "2015-07-01" @default.
• W2067291571 modified "2023-10-15" @default.
• W2067291571 title "CAD based design sensitivity analysis and shape optimization of scaffolds for bio-root regeneration in swine" @default.
• W2067291571 cites W1925863309 @default.
• W2067291571 cites W1969694533 @default.
• W2067291571 cites W1969937794 @default.
• W2067291571 cites W1971082090 @default.
• W2067291571 cites W1974608947 @default.
• W2067291571 cites W1979843087 @default.
• W2067291571 cites W1983966309 @default.
• W2067291571 cites W1985585174 @default.
• W2067291571 cites W1988635537 @default.
• W2067291571 cites W1988719248 @default.
• W2067291571 cites W1991123166 @default.
• W2067291571 cites W2001383750 @default.
• W2067291571 cites W2004776883 @default.
• W2067291571 cites W2010712560 @default.
• W2067291571 cites W2012022200 @default.
• W2067291571 cites W2015158617 @default.
• W2067291571 cites W2017687380 @default.
• W2067291571 cites W2025060786 @default.
• W2067291571 cites W2025670716 @default.
• W2067291571 cites W2027462945 @default.
• W2067291571 cites W2029593480 @default.
• W2067291571 cites W2035596893 @default.
• W2067291571 cites W2039322645 @default.
• W2067291571 cites W2041897038 @default.
• W2067291571 cites W2041965232 @default.
• W2067291571 cites W2049231058 @default.
• W2067291571 cites W2049886683 @default.
• W2067291571 cites W2054168815 @default.
• W2067291571 cites W2060735706 @default.
• W2067291571 cites W2061589325 @default.
• W2067291571 cites W2069631511 @default.
• W2067291571 cites W2076637530 @default.
• W2067291571 cites W2079876008 @default.
• W2067291571 cites W2088376206 @default.
• W2067291571 cites W2093430343 @default.
• W2067291571 cites W2094168324 @default.
• W2067291571 cites W2104911039 @default.
• W2067291571 cites W2123103984 @default.
• W2067291571 cites W2140410551 @default.
• W2067291571 cites W2143120881 @default.
• W2067291571 cites W2145615483 @default.
• W2067291571 cites W2148096755 @default.
• W2067291571 cites W2148562877 @default.
• W2067291571 cites W2151613878 @default.
• W2067291571 cites W2153083508 @default.
• W2067291571 cites W2158266980 @default.
• W2067291571 cites W2167018149 @default.
• W2067291571 cites W2168568923 @default.
• W2067291571 doi "https://doi.org/10.1016/j.biomaterials.2015.03.062" @default.
• W2067291571 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25913251" @default.
• W2067291571 hasPublicationYear "2015" @default.
• W2067291571 type Work @default.
• W2067291571 sameAs 2067291571 @default.
• W2067291571 citedByCount "41" @default.
• W2067291571 countsByYear W20672915712016 @default.
• W2067291571 countsByYear W20672915712017 @default.
• W2067291571 countsByYear W20672915712018 @default.
• W2067291571 countsByYear W20672915712019 @default.
• W2067291571 countsByYear W20672915712020 @default.
• W2067291571 countsByYear W20672915712021 @default.
• W2067291571 countsByYear W20672915712022 @default.
• W2067291571 countsByYear W20672915712023 @default.
• W2067291571 crossrefType "journal-article" @default.
• W2067291571 hasAuthorship W2067291571A5005793057 @default.
• W2067291571 hasAuthorship W2067291571A5019385672 @default.
• W2067291571 hasAuthorship W2067291571A5026143070 @default.
• W2067291571 hasAuthorship W2067291571A5042006674 @default.
• W2067291571 hasAuthorship W2067291571A5045067652 @default.
• W2067291571 hasAuthorship W2067291571A5046972210 @default.
• W2067291571 hasAuthorship W2067291571A5048868468 @default.
• W2067291571 hasAuthorship W2067291571A5054610344 @default.
• W2067291571 hasAuthorship W2067291571A5065859286 @default.
• W2067291571 hasAuthorship W2067291571A5076347170 @default.
• W2067291571 hasConcept C127413603 @default.
• W2067291571 hasConcept C135628077 @default.
• W2067291571 hasConcept C136229726 @default.
• W2067291571 hasConcept C138885662 @default.
• W2067291571 hasConcept C155165730 @default.
• W2067291571 hasConcept C159985019 @default.
• W2067291571 hasConcept C171056886 @default.
• W2067291571 hasConcept C192562407 @default.
• W2067291571 hasConcept C199343813 @default.
• W2067291571 hasConcept C21036866 @default.

• next