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- W2067306688 endingPage "844" @default.
- W2067306688 startingPage "833" @default.
- W2067306688 abstract "Orally administered targeted nanoparticles have a large number of potential biomedical applications and display several putative advantages for oral drug delivery, such as the protection of fragile drugs or modification of drug pharmacokinetics. These advantages notwithstanding, oral drug delivery by nanoparticles remains challenging. The optimization of particle size and surface properties and targeting by ligand grafting have been shown to enhance nanoparticle transport across the intestinal epithelium. Here, different grafting strategies for non-peptidic ligands, e.g., peptidomimetics, lectin mimetics, sugars and vitamins, that are stable in the gastrointestinal tract are discussed. We demonstrate that the grafting of these non-peptidic ligands allows nanoparticles to be targeted to M cells, enterocytes, immune cells or L cells. We show that these grafted nanoparticles could be promising vehicles for oral vaccination by targeting M cells or for the delivery of therapeutic proteins. We suggest that targeting L cells could be useful for the treatment of type 2 diabetes or obesity." @default.
- W2067306688 created "2016-06-24" @default.
- W2067306688 creator A5001987906 @default.
- W2067306688 creator A5021857885 @default.
- W2067306688 creator A5041828336 @default.
- W2067306688 creator A5070336660 @default.
- W2067306688 creator A5073045144 @default.
- W2067306688 date "2013-06-01" @default.
- W2067306688 modified "2023-10-18" @default.
- W2067306688 title "Targeted nanoparticles with novel non-peptidic ligands for oral delivery" @default.
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