FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2067315099> ?p ?o ?g. }

• W2067315099 endingPage "e1003305" @default.
• W2067315099 startingPage "e1003305" @default.
• W2067315099 abstract "Candida albicans can stochastically switch between two phenotypes, white and opaque. Opaque cells are the sexually competent form of C. albicans and therefore undergo efficient polarized growth and mating in the presence of pheromone. In contrast, white cells cannot mate, but are induced - under a specialized set of conditions - to form biofilms in response to pheromone. In this work, we compare the genetic regulation of such pheromone-stimulated biofilms with that of conventional C. albicans biofilms. In particular, we examined a network of six transcriptional regulators (Bcr1, Brg1, Efg1, Tec1, Ndt80, and Rob1) that mediate conventional biofilm formation for their potential roles in pheromone-stimulated biofilm formation. We show that four of the six transcription factors (Bcr1, Brg1, Rob1, and Tec1) promote formation of both conventional and pheromone-stimulated biofilms, indicating they play general roles in cell cohesion and biofilm development. In addition, we identify the master transcriptional regulator of pheromone-stimulated biofilms as C. albicans Cph1, ortholog of Saccharomyces cerevisiae Ste12. Cph1 regulates mating in C. albicans opaque cells, and here we show that Cph1 is also essential for pheromone-stimulated biofilm formation in white cells. In contrast, Cph1 is dispensable for the formation of conventional biofilms. The regulation of pheromone- stimulated biofilm formation was further investigated by transcriptional profiling and genetic analyses. These studies identified 196 genes that are induced by pheromone signaling during biofilm formation. One of these genes, HGC1, is shown to be required for both conventional and pheromone-stimulated biofilm formation. Taken together, these observations compare and contrast the regulation of conventional and pheromone-stimulated biofilm formation in C. albicans, and demonstrate that Cph1 is required for the latter, but not the former." @default.
• W2067315099 created "2016-06-24" @default.
• W2067315099 creator A5024622354 @default.
• W2067315099 creator A5028945409 @default.
• W2067315099 creator A5042377671 @default.
• W2067315099 creator A5048968028 @default.
• W2067315099 creator A5073689309 @default.
• W2067315099 creator A5080438053 @default.
• W2067315099 date "2013-04-18" @default.
• W2067315099 modified "2023-10-15" @default.
• W2067315099 title "Genetic Control of Conventional and Pheromone-Stimulated Biofilm Formation in Candida albicans" @default.
• W2067315099 cites W1509452146 @default.
• W2067315099 cites W1937936144 @default.
• W2067315099 cites W1938052804 @default.
• W2067315099 cites W1968109336 @default.
• W2067315099 cites W1976281822 @default.
• W2067315099 cites W1980587680 @default.
• W2067315099 cites W1990474165 @default.
• W2067315099 cites W2005869327 @default.
• W2067315099 cites W2009577007 @default.
• W2067315099 cites W2009927771 @default.
• W2067315099 cites W2021225422 @default.
• W2067315099 cites W2023555243 @default.
• W2067315099 cites W2024872322 @default.
• W2067315099 cites W2029849251 @default.
• W2067315099 cites W2036699947 @default.
• W2067315099 cites W2044192693 @default.
• W2067315099 cites W2044874029 @default.
• W2067315099 cites W2045825275 @default.
• W2067315099 cites W2049219353 @default.
• W2067315099 cites W2056868286 @default.
• W2067315099 cites W2062867942 @default.
• W2067315099 cites W2064795801 @default.
• W2067315099 cites W2066976786 @default.
• W2067315099 cites W2070589919 @default.
• W2067315099 cites W2070916151 @default.
• W2067315099 cites W2084426314 @default.
• W2067315099 cites W2085762947 @default.
• W2067315099 cites W2093492036 @default.
• W2067315099 cites W2099200899 @default.
• W2067315099 cites W2100721452 @default.
• W2067315099 cites W2101824673 @default.
• W2067315099 cites W2103713889 @default.
• W2067315099 cites W2115071266 @default.
• W2067315099 cites W2118759693 @default.
• W2067315099 cites W2120191560 @default.
• W2067315099 cites W2120232022 @default.
• W2067315099 cites W2122575278 @default.
• W2067315099 cites W2125270417 @default.
• W2067315099 cites W2126966227 @default.
• W2067315099 cites W2128207311 @default.
• W2067315099 cites W2128849746 @default.
• W2067315099 cites W2130264765 @default.
• W2067315099 cites W2131213513 @default.
• W2067315099 cites W2133083377 @default.
• W2067315099 cites W2140109029 @default.
• W2067315099 cites W2141595874 @default.
• W2067315099 cites W2142140971 @default.
• W2067315099 cites W2155458286 @default.
• W2067315099 cites W2158313582 @default.
• W2067315099 cites W2158592372 @default.
• W2067315099 cites W2158611476 @default.
• W2067315099 cites W2161674021 @default.
• W2067315099 cites W2163260362 @default.
• W2067315099 cites W2164464413 @default.
• W2067315099 cites W2165957892 @default.
• W2067315099 cites W2171510356 @default.
• W2067315099 cites W2171548303 @default.
• W2067315099 doi "https://doi.org/10.1371/journal.ppat.1003305" @default.
• W2067315099 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3630098" @default.
• W2067315099 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23637598" @default.
• W2067315099 hasPublicationYear "2013" @default.
• W2067315099 type Work @default.
• W2067315099 sameAs 2067315099 @default.
• W2067315099 citedByCount "81" @default.
• W2067315099 countsByYear W20673150992013 @default.
• W2067315099 countsByYear W20673150992014 @default.
• W2067315099 countsByYear W20673150992015 @default.
• W2067315099 countsByYear W20673150992016 @default.
• W2067315099 countsByYear W20673150992017 @default.
• W2067315099 countsByYear W20673150992018 @default.
• W2067315099 countsByYear W20673150992019 @default.
• W2067315099 countsByYear W20673150992020 @default.
• W2067315099 countsByYear W20673150992021 @default.
• W2067315099 countsByYear W20673150992022 @default.
• W2067315099 countsByYear W20673150992023 @default.
• W2067315099 crossrefType "journal-article" @default.
• W2067315099 hasAuthorship W2067315099A5024622354 @default.
• W2067315099 hasAuthorship W2067315099A5028945409 @default.
• W2067315099 hasAuthorship W2067315099A5042377671 @default.
• W2067315099 hasAuthorship W2067315099A5048968028 @default.
• W2067315099 hasAuthorship W2067315099A5073689309 @default.
• W2067315099 hasAuthorship W2067315099A5080438053 @default.
• W2067315099 hasBestOaLocation W20673150991 @default.
• W2067315099 hasConcept C118687296 @default.
• W2067315099 hasConcept C145081991 @default.
• W2067315099 hasConcept C2777328355 @default.
• W2067315099 hasConcept C2780917455 @default.

• next