Matches in SemOpenAlex for { <https://semopenalex.org/work/W2067315145> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2067315145 endingPage "169" @default.
- W2067315145 startingPage "161" @default.
- W2067315145 abstract "We recently reported the phenomenon of retroviral insertion into a herpesvirus (Isfort et al., (1992) Proc. Natl. Acad. Sci. USA 89, 991-995). We have now isolated Marek's disease virus (MDV) clones that carry retroviral inserts. Retroviral LTR insertion has the potential to activate or inactivate herpesvirus genes leading to alterations of the biological properties of the herpesviruses. The structure and the expression pattern of a virus clone carrying a solitary LTR insertion was characterized in detail. The LTR insertion is accompanied by deletions in the herpesvirus genome at each of the junctions of the short unique region (US) and its inverted repeats (RS). This results in a significantly truncated RS region. Despite these structural rearrangements, the virus is replication-competent and demonstrates an enhanced growth rate in vitro. While the MDV homologs of herpes simplex US genes are retained in this virus, at least two open reading frames are deleted and one transcript observed in wild-type virus is disrupted. In addition to defining several regions of MDV that are nonessential for in vitro growth, this clone illustrates one way in which retroviral information can be stably transmitted by a herpesvirus." @default.
- W2067315145 created "2016-06-24" @default.
- W2067315145 creator A5003080361 @default.
- W2067315145 creator A5018732697 @default.
- W2067315145 creator A5024000968 @default.
- W2067315145 creator A5053333537 @default.
- W2067315145 creator A5069129723 @default.
- W2067315145 date "1993-01-01" @default.
- W2067315145 modified "2023-09-23" @default.
- W2067315145 title "Retrovirus Insertion into Herpesvirus: Characterization of a Marek's Disease Virus Harboring a Solo LTR" @default.
- W2067315145 doi "https://doi.org/10.1006/viro.1993.1018" @default.
- W2067315145 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8390750" @default.
- W2067315145 hasPublicationYear "1993" @default.
- W2067315145 type Work @default.
- W2067315145 sameAs 2067315145 @default.
- W2067315145 citedByCount "48" @default.
- W2067315145 countsByYear W20673151452012 @default.
- W2067315145 countsByYear W20673151452013 @default.
- W2067315145 countsByYear W20673151452014 @default.
- W2067315145 countsByYear W20673151452015 @default.
- W2067315145 countsByYear W20673151452016 @default.
- W2067315145 countsByYear W20673151452017 @default.
- W2067315145 countsByYear W20673151452019 @default.
- W2067315145 countsByYear W20673151452020 @default.
- W2067315145 countsByYear W20673151452022 @default.
- W2067315145 crossrefType "journal-article" @default.
- W2067315145 hasAuthorship W2067315145A5003080361 @default.
- W2067315145 hasAuthorship W2067315145A5018732697 @default.
- W2067315145 hasAuthorship W2067315145A5024000968 @default.
- W2067315145 hasAuthorship W2067315145A5053333537 @default.
- W2067315145 hasAuthorship W2067315145A5069129723 @default.
- W2067315145 hasConcept C104317684 @default.
- W2067315145 hasConcept C141231307 @default.
- W2067315145 hasConcept C159047783 @default.
- W2067315145 hasConcept C199491388 @default.
- W2067315145 hasConcept C2522874641 @default.
- W2067315145 hasConcept C2777852405 @default.
- W2067315145 hasConcept C2778431562 @default.
- W2067315145 hasConcept C2781196997 @default.
- W2067315145 hasConcept C54355233 @default.
- W2067315145 hasConcept C81089528 @default.
- W2067315145 hasConcept C86803240 @default.
- W2067315145 hasConceptScore W2067315145C104317684 @default.
- W2067315145 hasConceptScore W2067315145C141231307 @default.
- W2067315145 hasConceptScore W2067315145C159047783 @default.
- W2067315145 hasConceptScore W2067315145C199491388 @default.
- W2067315145 hasConceptScore W2067315145C2522874641 @default.
- W2067315145 hasConceptScore W2067315145C2777852405 @default.
- W2067315145 hasConceptScore W2067315145C2778431562 @default.
- W2067315145 hasConceptScore W2067315145C2781196997 @default.
- W2067315145 hasConceptScore W2067315145C54355233 @default.
- W2067315145 hasConceptScore W2067315145C81089528 @default.
- W2067315145 hasConceptScore W2067315145C86803240 @default.
- W2067315145 hasIssue "1" @default.
- W2067315145 hasLocation W20673151451 @default.
- W2067315145 hasLocation W20673151452 @default.
- W2067315145 hasOpenAccess W2067315145 @default.
- W2067315145 hasPrimaryLocation W20673151451 @default.
- W2067315145 hasRelatedWork W1532002686 @default.
- W2067315145 hasRelatedWork W1565219848 @default.
- W2067315145 hasRelatedWork W1605241955 @default.
- W2067315145 hasRelatedWork W1907186493 @default.
- W2067315145 hasRelatedWork W1980880357 @default.
- W2067315145 hasRelatedWork W2067315145 @default.
- W2067315145 hasRelatedWork W2142049433 @default.
- W2067315145 hasRelatedWork W2351571969 @default.
- W2067315145 hasRelatedWork W72687520 @default.
- W2067315145 hasRelatedWork W74685249 @default.
- W2067315145 hasVolume "192" @default.
- W2067315145 isParatext "false" @default.
- W2067315145 isRetracted "false" @default.
- W2067315145 magId "2067315145" @default.
- W2067315145 workType "article" @default.