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• W2067315620 endingPage "570" @default.
• W2067315620 startingPage "559" @default.
• W2067315620 abstract "•The human hair follicle (HF) is a source and target of numerous neuromediators. •These regulate diverse HF functions, including growth, stem cell, and immune status. •Organ culture of human scalp HFs can identify novel functions of neuromediators. The human hair follicle (HF) is an exquisitely hormone-sensitive mini-organ that undergoes cyclical remodeling. It is also a source and target of numerous neurohormones, neuropeptides, and neurotransmitters that regulate HF growth, pigmentation, remodeling, immune status, stem cell biology, and energy metabolism. Indeed, organ-cultured human scalp HFs can be utilized to identify ‘novel’ clinically relevant functions of major neuromediators. This is pertinently illustrated by the discoveries of: (i) thyrotropin-releasing hormone (TRH) as a hair growth and pigmentation stimulator; (ii) TRH and thyrotropin (TSH) as potent promoters of mitochondrial activity and regulators of keratin expression; and (iii) prolactin as an epithelial stem cell modulator. Thus, HF neuroendocrinology affords insights well beyond hair growth and dermatoendocrinology, uncovering new translationally relevant neuroendocrinology principles and novel therapeutic targets. The human hair follicle (HF) is an exquisitely hormone-sensitive mini-organ that undergoes cyclical remodeling. It is also a source and target of numerous neurohormones, neuropeptides, and neurotransmitters that regulate HF growth, pigmentation, remodeling, immune status, stem cell biology, and energy metabolism. Indeed, organ-cultured human scalp HFs can be utilized to identify ‘novel’ clinically relevant functions of major neuromediators. This is pertinently illustrated by the discoveries of: (i) thyrotropin-releasing hormone (TRH) as a hair growth and pigmentation stimulator; (ii) TRH and thyrotropin (TSH) as potent promoters of mitochondrial activity and regulators of keratin expression; and (iii) prolactin as an epithelial stem cell modulator. Thus, HF neuroendocrinology affords insights well beyond hair growth and dermatoendocrinology, uncovering new translationally relevant neuroendocrinology principles and novel therapeutic targets." @default.
• W2067315620 created "2016-06-24" @default.
• W2067315620 creator A5037894981 @default.
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• W2067315620 creator A5067149232 @default.
• W2067315620 creator A5082322510 @default.
• W2067315620 creator A5087513808 @default.
• W2067315620 date "2014-10-01" @default.
• W2067315620 modified "2023-09-30" @default.
• W2067315620 title "Neuroendocrinology of the hair follicle: principles and clinical perspectives" @default.
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