FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2067339620> ?p ?o ?g. }

• W2067339620 endingPage "60" @default.
• W2067339620 startingPage "49" @default.
• W2067339620 abstract "The present study aimed to investigate the potential roles of spinal microglia and downstream molecules in the induction of spinal long-term potentiation (LTP) and mechanical allodynia by tetanic stimulation of the sciatic nerve (TSS).Spinal LTP was induced in adult male Sprague-Dawley rats by tetanic stimulation of the sciatic nerve (0.5 ms, 100 Hz, 40 V, 10 trains of 2-s duration at 10-s intervals). Mechanical allodynia was determined using von Frey hairs. Immunohistochemical staining and Western blot were used to detect changes in glial expression of interleukin-18 (IL-18) and IL-18 receptor (IL-18R).TSS induced LTP of C-fiber-evoked field potentials in the spinal cord. Intrathecal administration of the microglial inhibitor minocycline (200 μg/20 μL) 1 h before TSS completely blocked the induction of spinal LTP. Furthermore, after intrathecal injection of minocycline (200 μg/20 μL) by lumbar puncture 1 h before TSS, administration of minocycline for 7 consecutive days (once per day) partly inhibited bilateral allodynia. Immunohistochemistry showed that minocycline inhibited the sequential activation of microglia and astrocytes, and IL-18 was predominantly colocalized with the microglial marker Iba-1 in the spinal superficial dorsal horn. Western blot revealed that repeated intrathecal injection of minocycline significantly inhibited the increased expression of IL-18 and IL-18Rs in microglia induced by TSS.The IL-18 signaling pathway in microglia is involved in TSS-induced spinal LTP and mechanical allodynia." @default.
• W2067339620 created "2016-06-24" @default.
• W2067339620 creator A5031720142 @default.
• W2067339620 creator A5064626583 @default.
• W2067339620 creator A5088189767 @default.
• W2067339620 date "2012-01-25" @default.
• W2067339620 modified "2023-10-13" @default.
• W2067339620 title "Involvement of microglia and interleukin-18 in the induction of long-term potentiation of spinal nociceptive responses induced by tetanic sciatic stimulation" @default.
• W2067339620 cites W103811464 @default.
• W2067339620 cites W1535641516 @default.
• W2067339620 cites W1548862642 @default.
• W2067339620 cites W1766369466 @default.
• W2067339620 cites W1883377612 @default.
• W2067339620 cites W1964121216 @default.
• W2067339620 cites W1966234453 @default.
• W2067339620 cites W1970954587 @default.
• W2067339620 cites W1976219259 @default.
• W2067339620 cites W1979859079 @default.
• W2067339620 cites W1984025105 @default.
• W2067339620 cites W1987945720 @default.
• W2067339620 cites W1992987958 @default.
• W2067339620 cites W1994229109 @default.
• W2067339620 cites W1998465031 @default.
• W2067339620 cites W2006161356 @default.
• W2067339620 cites W2007156132 @default.
• W2067339620 cites W2009812771 @default.
• W2067339620 cites W2016448869 @default.
• W2067339620 cites W2018689514 @default.
• W2067339620 cites W2027130667 @default.
• W2067339620 cites W2032952262 @default.
• W2067339620 cites W2036289756 @default.
• W2067339620 cites W2040443501 @default.
• W2067339620 cites W2041008164 @default.
• W2067339620 cites W2041562559 @default.
• W2067339620 cites W2044597171 @default.
• W2067339620 cites W2049183025 @default.
• W2067339620 cites W2051050975 @default.
• W2067339620 cites W2056200351 @default.
• W2067339620 cites W2063153146 @default.
• W2067339620 cites W2067761092 @default.
• W2067339620 cites W2070312747 @default.
• W2067339620 cites W2079840847 @default.
• W2067339620 cites W2081486880 @default.
• W2067339620 cites W2083212123 @default.
• W2067339620 cites W2088062805 @default.
• W2067339620 cites W2091525965 @default.
• W2067339620 cites W2091655648 @default.
• W2067339620 cites W2101341122 @default.
• W2067339620 cites W2116064885 @default.
• W2067339620 cites W2122778405 @default.
• W2067339620 cites W2127070923 @default.
• W2067339620 cites W2132573038 @default.
• W2067339620 cites W2137648115 @default.
• W2067339620 cites W2170019750 @default.
• W2067339620 cites W2292011272 @default.
• W2067339620 cites W4249255014 @default.
• W2067339620 cites W90799786 @default.
• W2067339620 doi "https://doi.org/10.1007/s12264-012-1058-4" @default.
• W2067339620 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5560287" @default.
• W2067339620 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22233889" @default.
• W2067339620 hasPublicationYear "2012" @default.
• W2067339620 type Work @default.
• W2067339620 sameAs 2067339620 @default.
• W2067339620 citedByCount "23" @default.
• W2067339620 countsByYear W20673396202013 @default.
• W2067339620 countsByYear W20673396202014 @default.
• W2067339620 countsByYear W20673396202015 @default.
• W2067339620 countsByYear W20673396202017 @default.
• W2067339620 countsByYear W20673396202018 @default.
• W2067339620 countsByYear W20673396202019 @default.
• W2067339620 countsByYear W20673396202020 @default.
• W2067339620 countsByYear W20673396202021 @default.
• W2067339620 countsByYear W20673396202023 @default.
• W2067339620 crossrefType "journal-article" @default.
• W2067339620 hasAuthorship W2067339620A5031720142 @default.
• W2067339620 hasAuthorship W2067339620A5064626583 @default.
• W2067339620 hasAuthorship W2067339620A5088189767 @default.
• W2067339620 hasBestOaLocation W20673396202 @default.
• W2067339620 hasConcept C118552586 @default.
• W2067339620 hasConcept C126322002 @default.
• W2067339620 hasConcept C15490471 @default.
• W2067339620 hasConcept C169760540 @default.
• W2067339620 hasConcept C170493617 @default.
• W2067339620 hasConcept C185592680 @default.
• W2067339620 hasConcept C24998067 @default.
• W2067339620 hasConcept C25274449 @default.
• W2067339620 hasConcept C2776328245 @default.
• W2067339620 hasConcept C2776914184 @default.
• W2067339620 hasConcept C2777107010 @default.
• W2067339620 hasConcept C2777883359 @default.
• W2067339620 hasConcept C2778275353 @default.
• W2067339620 hasConcept C2779245659 @default.
• W2067339620 hasConcept C2779830541 @default.
• W2067339620 hasConcept C2780775167 @default.
• W2067339620 hasConcept C2781149210 @default.
• W2067339620 hasConcept C42219234 @default.
• W2067339620 hasConcept C501593827 @default.
• W2067339620 hasConcept C55493867 @default.

• next