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• W2067356449 endingPage "41" @default.
• W2067356449 startingPage "23" @default.
• W2067356449 abstract "Parahippocampal gyrus was sampled from human brains at autopsy to form three groups: adult (n = 5, mean age 51.2 years), normal aged (n = 5, mean age 79.6), and senile dementia (SD) (n = 5, mean age 76.0). Classification as normal aged or senile demented was based on both behavioral and neuropathological criteria. Tissue was processed for Golgi-Cox, cresyl violet, hematoxylin and eosin and Bodian silver stains. Both atrophied and normal dendritic trees were seen in all cases. Dendrites of layer II pyramidal neurons were quantified with a computer-microscope system. Quantitative data showed that normal aged individuals had longer and more branched dendrites than either adult or SD individuals. There was a slight tendency for SD individuals to have shorter, less-branched dendrites than adults. Differences among groups were greater in apical than in basal portions of the dendritic tree. These differences were largely accounted for by the lengthening and branching (apical dendrites) or lengthening only (basal dendrites) of terminal dendritic segments. These data suggest a model in which aging cortex contains both regressing, dying neurons and surviving, growing neurons. In normal aging it is the latter group that predominates. This is the first demonstration of plasticity in the adult human brain." @default.
• W2067356449 created "2016-06-24" @default.
• W2067356449 creator A5039480022 @default.
• W2067356449 creator A5074137490 @default.
• W2067356449 date "1981-06-01" @default.
• W2067356449 modified "2023-10-11" @default.
• W2067356449 title "Quantitative evidence for selective dendritic growth in normal human aging but not in senile dementia" @default.
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• W2067356449 doi "https://doi.org/10.1016/0006-8993(81)90436-4" @default.
• W2067356449 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7237164" @default.
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