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- W2067364582 abstract "The in vitro inhibitory effect of glycopyrrolate and atropine on the hydrolysis of benzoylcholine at 50.0 εM concentration was determined in the plasma of 6 healthy volunteers at 37° C and at 240 nm by the ultraviolet spectrophotometric method of Kalow. The 50 per cent inhibitory concentration (I50) of glycopyrrolate was found to be 1.0 mM and the I50 of atropine was 0.9 mM. This inhibitory effect of glycopyrrolate and atropine is moderate but its interaction with the in vivo hydrolysis of succinylcholine or that of ester-type of local anaesthetics in patients should be further studied. Although both glycopyrrolate and atropine inhibit PChE to the same extent, glycopyrrolate should be utilized in patients in whom inhibition of brain PChE or central effects ought to be avoided, since glycopyrrolate does not penetrate the blood-brain barrier." @default.
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- W2067364582 date "1985-01-01" @default.
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- W2067364582 title "The inhibitory effect of glycopyrrolate on human plasmacholinesterase" @default.
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- W2067364582 doi "https://doi.org/10.1007/bf03008533" @default.
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