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• W2067366063 startingPage "3282" @default.
• W2067366063 abstract "A new ligand and two ruthenium(II) complexes [Ru(bpy)2(DNPIP)](ClO4)2 1 and [Ru(bpy)2(DAPIP)](ClO4)2 2 were synthesized and characterized. The DNA-binding constants for complexes 1 and 2 were determined to be 2.24 (±0.30) × 105 M−1 (s = 1.29) and 6.34 (±0.32) × 104 M−1 (s = 2.84). The photocleavage of pBR322 DNA by Ru(II) complexes was investigated. The cytotoxicity of complexes 1 and 2 were assessed against three tumor cell lines. The apoptosis and cellular uptake were studied. The retardation assay of pGL 3 plasmid DNA was explored. The cell cycle arrest was analysized by flow cytometry. The antioxidant activities of the ligand and complexes were also investigated." @default.
• W2067366063 created "2016-06-24" @default.
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• W2067366063 date "2011-08-01" @default.
• W2067366063 modified "2023-10-18" @default.
• W2067366063 title "Synthesis, cellular uptake, apopotosis, cytotoxicity, cell cycle arrest, interaction with DNA and antioxidant activity of ruthenium(II) complexes" @default.
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• W2067366063 doi "https://doi.org/10.1016/j.ejmech.2011.04.049" @default.
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