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• W2067367410 endingPage "193" @default.
• W2067367410 startingPage "187" @default.
• W2067367410 abstract "Pancreatic β-cells secrete insulin in response to elevated blood glucose via Ca2+-dependent fusion of secretory granules with the plasma membrane (regulated exocytosis). While exocytosis has been extensively investigated in rodent β-cells, studies on human β-cells are scarce. We have characterized the exocytotic properties of human β-cells by insulin release measurements, carbon fiber amperometry, and capacitance measurements using the patch-clamp technique. Voltage-clamp depolarizations evoked capacitance increases in single β-cells in a time- and voltage-dependent manner. The capacitance responses as well as insulin release from intact islets were strongly amplified by elevation of intracellular cAMP levels. Exocytosis was more dependent on Ca2+ influx through P/Q-type than L-type Ca2+ channels, reflecting the relative contribution of these channels to the total Ca2+ current. Exocytosis (as monitored by capacitance or amperometric measurements) decreased during repetitive stimulation as a result of inactivation of Ca2+ channels as well as depletion of a readily releasable pool of granules. These results reveal both similarities and differences between human and rodent β-cells." @default.
• W2067367410 created "2016-06-24" @default.
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• W2067367410 date "2009-01-01" @default.
• W2067367410 modified "2023-10-05" @default.
• W2067367410 title "Exocytotic Properties of Human Pancreatic β-cells" @default.
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• W2067367410 doi "https://doi.org/10.1111/j.1749-6632.2008.03992.x" @default.
• W2067367410 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19161389" @default.
• W2067367410 hasPublicationYear "2009" @default.
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