Matches in SemOpenAlex for { <https://semopenalex.org/work/W2067374467> ?p ?o ?g. }
- W2067374467 endingPage "644" @default.
- W2067374467 startingPage "638" @default.
- W2067374467 abstract "Interleukin (IL)-1 is a highly active and pleiotropic pro-inflammatory cytokine. Recent data impressively demonstrate that activating mutations in a human gene involved in proIL-1β maturation or loss-of-function mutations in the gene encoding IL-1 receptor antagonist (IL-1Ra) cause excessive activity of this cytokine. This can result in life-threatening systemic and local inflammation, particularly in the skin. Interestingly, experiments in mice revealed that epidermal keratinocytes can secrete large amounts of IL-1α, which induces an inflammatory response in the skin. Secretion of IL-1 requires caspase-1 activity, and activation of the protease takes place in innate immune complexes, called inflammasomes. As keratinocytes express and activate caspase-1 in an inflammasome-dependent manner, these epithelial cells might be critically involved in the innate immunity of the skin. In this review we summarize the current knowledge on IL-1 and inflammasomes in the skin, particularly their involvement in skin homeostasis and disease. In addition, we discuss the hypothesis that keratinocytes are not only static bricks of the epidermal wall, but immunologically active cells critically involved in different (auto)-inflammatory (skin) diseases." @default.
- W2067374467 created "2016-06-24" @default.
- W2067374467 creator A5017961900 @default.
- W2067374467 creator A5021906809 @default.
- W2067374467 creator A5056144634 @default.
- W2067374467 creator A5077079745 @default.
- W2067374467 date "2010-09-01" @default.
- W2067374467 modified "2023-10-18" @default.
- W2067374467 title "Interleukin-1, inflammasomes and the skin" @default.
- W2067374467 cites W1529674879 @default.
- W2067374467 cites W1529895897 @default.
- W2067374467 cites W1533217355 @default.
- W2067374467 cites W1591918677 @default.
- W2067374467 cites W1593319850 @default.
- W2067374467 cites W1607784912 @default.
- W2067374467 cites W189195583 @default.
- W2067374467 cites W1921587687 @default.
- W2067374467 cites W1963492948 @default.
- W2067374467 cites W1964977785 @default.
- W2067374467 cites W1965642261 @default.
- W2067374467 cites W1967060514 @default.
- W2067374467 cites W1967436988 @default.
- W2067374467 cites W1968182403 @default.
- W2067374467 cites W1972452655 @default.
- W2067374467 cites W1973329998 @default.
- W2067374467 cites W1978462186 @default.
- W2067374467 cites W1983424467 @default.
- W2067374467 cites W1987287925 @default.
- W2067374467 cites W1989305669 @default.
- W2067374467 cites W1992359197 @default.
- W2067374467 cites W1997080155 @default.
- W2067374467 cites W1998574307 @default.
- W2067374467 cites W1999276471 @default.
- W2067374467 cites W1999406693 @default.
- W2067374467 cites W2008261126 @default.
- W2067374467 cites W2018433301 @default.
- W2067374467 cites W2024378513 @default.
- W2067374467 cites W2028772793 @default.
- W2067374467 cites W2028857382 @default.
- W2067374467 cites W2031084334 @default.
- W2067374467 cites W2031745594 @default.
- W2067374467 cites W2038143978 @default.
- W2067374467 cites W2041935246 @default.
- W2067374467 cites W2042194530 @default.
- W2067374467 cites W2042648849 @default.
- W2067374467 cites W2047868805 @default.
- W2067374467 cites W2051431712 @default.
- W2067374467 cites W2055567016 @default.
- W2067374467 cites W2057039052 @default.
- W2067374467 cites W2060995513 @default.
- W2067374467 cites W2062143882 @default.
- W2067374467 cites W2064672822 @default.
- W2067374467 cites W2065154189 @default.
- W2067374467 cites W2065330071 @default.
- W2067374467 cites W2065635384 @default.
- W2067374467 cites W2065937204 @default.
- W2067374467 cites W2072570721 @default.
- W2067374467 cites W2082264631 @default.
- W2067374467 cites W2082821194 @default.
- W2067374467 cites W2083236593 @default.
- W2067374467 cites W2084981002 @default.
- W2067374467 cites W2093329656 @default.
- W2067374467 cites W2099808663 @default.
- W2067374467 cites W2102550380 @default.
- W2067374467 cites W2103806424 @default.
- W2067374467 cites W2114769428 @default.
- W2067374467 cites W2117439999 @default.
- W2067374467 cites W2120815988 @default.
- W2067374467 cites W2121560754 @default.
- W2067374467 cites W2130153302 @default.
- W2067374467 cites W2140996651 @default.
- W2067374467 cites W2141939334 @default.
- W2067374467 cites W2148795627 @default.
- W2067374467 cites W2153365712 @default.
- W2067374467 cites W2159587574 @default.
- W2067374467 cites W2165239282 @default.
- W2067374467 cites W2165275387 @default.
- W2067374467 cites W2170820723 @default.
- W2067374467 cites W2561759163 @default.
- W2067374467 doi "https://doi.org/10.1016/j.ejcb.2010.04.008" @default.
- W2067374467 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20605059" @default.
- W2067374467 hasPublicationYear "2010" @default.
- W2067374467 type Work @default.
- W2067374467 sameAs 2067374467 @default.
- W2067374467 citedByCount "124" @default.
- W2067374467 countsByYear W20673744672012 @default.
- W2067374467 countsByYear W20673744672013 @default.
- W2067374467 countsByYear W20673744672014 @default.
- W2067374467 countsByYear W20673744672015 @default.
- W2067374467 countsByYear W20673744672016 @default.
- W2067374467 countsByYear W20673744672017 @default.
- W2067374467 countsByYear W20673744672018 @default.
- W2067374467 countsByYear W20673744672019 @default.
- W2067374467 countsByYear W20673744672020 @default.
- W2067374467 countsByYear W20673744672021 @default.
- W2067374467 countsByYear W20673744672022 @default.
- W2067374467 countsByYear W20673744672023 @default.
- W2067374467 crossrefType "journal-article" @default.