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- W2067378410 abstract "To examine the effectiveness of activity-initiated rate-responsive pacing, this study assessed the increases in stroke volume and cardiac output during randomized treadmill exercise in rate-responsive and fixed-rate ventricular (VVI) pacing in 10 patients. Stroke volume index and cardiac index were determined by suprasternal Doppler measurements. Compared with the findings during VVI pacing, the rate-responsive pacing was associated with (1) prolongation of exercise duration (8.0 ± 4.0 vs 7.3 ± 3.6 minutes, p < 0.05); (2) greater exerciseinduced positive chronotropic response (mean maximal heart rate 127 ± 12 vs 78 ± 15 beats/min, p < 0.001); (3) smaller increase in stroke volume index (38 ± 10 vs 50 ± 11 ml/m2, p < 0.001), and (4) greater increase in cardiac index (4.7 ± 1.1 vs 3.9 ± 1.0 liters/min/m2, p < 0.001). A significant correlation was observed between age and percent increase in stroke volume index during VVI pacing (p < 0.05). These findings indicate that VVI pacing increased stroke volume more than did rate-responsive pacing, especially in younger patients, but the increase in cardiac output was less than that seen with rate-responsive pacing due to the absence of chronotropic response. Accordingly, an activity-sensing, rate-responsive pacemaker can effectively increase the heart rate, significantly augment cardiac output and extend the duration of exercise." @default.
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- W2067378410 date "1989-04-01" @default.
- W2067378410 modified "2023-09-27" @default.
- W2067378410 title "Evaluation by exercise doppler echocardiography of maintenance of cardiac output during ventricular pacing with or without chronotropic response" @default.
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- W2067378410 doi "https://doi.org/10.1016/0002-9149(89)90143-4" @default.
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