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- W2067381505 abstract "Nutlin-3, a small molecule inhibitor of the MDM2/p53 interaction, has been recently taken into consideration as a promising therapeutic tool for tumor treatment based on its ability to stabilize and activate the p53 transcription factor pathway. Since Nutlin-3 displays non cell-autonomous tumor-suppressor activities, we wanted to investigate its effect on dendritic cell functions, given the central role of these cells in the modulation of the immune response. We found that Nutlin-3 alone slightly affected the levels of major histocompatibility complex and costimulatory molecules and significantly promoted the ability of dendritic cells to stimulate T cells in the mixed lymphocyte reaction. Taken together, our findings suggest that the ability of Nutlin-3 to modulate dendritic cell functions and therefore lymphocyte proliferation might represent an additional important mechanism by which Nutlin-3 exerts its non cell-autonomous tumor-suppression function." @default.
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- W2067381505 date "2012-04-01" @default.
- W2067381505 modified "2023-09-25" @default.
- W2067381505 title "The MDM2 inhibitor Nutlin-3 modulates dendritic cell–induced T cell proliferation" @default.
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- W2067381505 doi "https://doi.org/10.1016/j.humimm.2012.01.018" @default.
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