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- W2067382092 abstract "A major reason for the insufficient recovery of function after motor nerve injury are the numerous axonal branches which often re-innervate muscles with completely different functions. We hypothesized that a neutralization of diffusable neurotrophic factors at the lesion site in rats could reduce the branching of transected axons. Following analysis of local protein expression by immunocytochemistry and by in situ hybridization, we transected the facial nerve trunk of adult rats and inserted both ends into a silicon tube containing (i) collagen gel with neutralizing concentrations of antibodies to NGF, BDNF, bFGF, IGF-I, CNTF and GDNF; (ii) five-fold higher concentrations of the antibodies and (iii) combination of antibodies. Two months later, retrograde labelling was used to estimate the portion of motoneurons the axons of which had branched and projected into three major branches of the facial trunk. After control entubulation in collagen gel containing non-immune mouse IgG 85% of all motoneurons projecting along the zygomatic branch sprouted and sent at least one twin axon to the buccal and/or marginal-mandibular branches of the facial nerve. Neutralizing concentrations of anti-NGF, anti-BDNF and anti-IGF-I significantly reduced sprouting. The most pronounced effect was achieved after application of anti-BDNF, which reduced the portion of branched neurons to 18%. All effects after a single application of antibodies were concentration-dependent and superior to those observed after combined treatment. This first report on improved quality of reinnervation by antibody-therapy implies that, in rats, the post-transectional collateral axonal branching can be reduced without obvious harmful effects on neuronal survival and axonal elongation." @default.
- W2067382092 created "2016-06-24" @default.
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- W2067382092 date "2002-04-01" @default.
- W2067382092 modified "2023-10-09" @default.
- W2067382092 title "Focal application of neutralizing antibodies to soluble neurotrophic factors reduces collateral axonal branching after peripheral nerve lesion" @default.
- W2067382092 cites W116915451 @default.
- W2067382092 cites W1491409303 @default.
- W2067382092 cites W1605889901 @default.
- W2067382092 cites W1610056203 @default.
- W2067382092 cites W1612950486 @default.
- W2067382092 cites W1661937675 @default.
- W2067382092 cites W1865290313 @default.
- W2067382092 cites W1884408152 @default.
- W2067382092 cites W1896852852 @default.
- W2067382092 cites W1898813276 @default.
- W2067382092 cites W1919911722 @default.
- W2067382092 cites W1935791859 @default.
- W2067382092 cites W19429020 @default.
- W2067382092 cites W1963594438 @default.
- W2067382092 cites W1964837678 @default.
- W2067382092 cites W1965352187 @default.
- W2067382092 cites W1965451339 @default.
- W2067382092 cites W1966404524 @default.
- W2067382092 cites W1966460505 @default.
- W2067382092 cites W1970611360 @default.
- W2067382092 cites W1974591313 @default.
- W2067382092 cites W1976347436 @default.
- W2067382092 cites W1976857475 @default.
- W2067382092 cites W1981154529 @default.
- W2067382092 cites W1981238340 @default.
- W2067382092 cites W1982236825 @default.
- W2067382092 cites W1982415930 @default.
- W2067382092 cites W1983777466 @default.
- W2067382092 cites W1984218330 @default.
- W2067382092 cites W1985682605 @default.
- W2067382092 cites W1986062352 @default.
- W2067382092 cites W1986540755 @default.
- W2067382092 cites W1986794946 @default.
- W2067382092 cites W1989431626 @default.
- W2067382092 cites W1990590034 @default.
- W2067382092 cites W1991236312 @default.
- W2067382092 cites W1991967557 @default.
- W2067382092 cites W1993527726 @default.
- W2067382092 cites W1994794966 @default.
- W2067382092 cites W1995374378 @default.
- W2067382092 cites W1996436631 @default.
- W2067382092 cites W1998028567 @default.
- W2067382092 cites W1998108670 @default.
- W2067382092 cites W1998367902 @default.
- W2067382092 cites W2000250641 @default.
- W2067382092 cites W2000540402 @default.
- W2067382092 cites W2001148555 @default.
- W2067382092 cites W2002853488 @default.
- W2067382092 cites W2006913118 @default.
- W2067382092 cites W2008288388 @default.
- W2067382092 cites W2008983110 @default.
- W2067382092 cites W2010186412 @default.
- W2067382092 cites W2010219735 @default.
- W2067382092 cites W2012277836 @default.
- W2067382092 cites W2012838494 @default.
- W2067382092 cites W2014903473 @default.
- W2067382092 cites W2015041369 @default.
- W2067382092 cites W2017206399 @default.
- W2067382092 cites W2021054927 @default.
- W2067382092 cites W2029581452 @default.
- W2067382092 cites W2030807678 @default.
- W2067382092 cites W2031675916 @default.
- W2067382092 cites W2031930530 @default.
- W2067382092 cites W2032620009 @default.
- W2067382092 cites W2033024884 @default.
- W2067382092 cites W2035762505 @default.
- W2067382092 cites W2040358411 @default.
- W2067382092 cites W2043632422 @default.
- W2067382092 cites W2045423842 @default.
- W2067382092 cites W2046472745 @default.
- W2067382092 cites W2046593551 @default.
- W2067382092 cites W2047960520 @default.
- W2067382092 cites W2048240343 @default.
- W2067382092 cites W2049267143 @default.
- W2067382092 cites W2049843885 @default.
- W2067382092 cites W2050838682 @default.
- W2067382092 cites W2051556688 @default.
- W2067382092 cites W2052106777 @default.
- W2067382092 cites W2054113611 @default.
- W2067382092 cites W2054365884 @default.
- W2067382092 cites W2066135701 @default.
- W2067382092 cites W2067857710 @default.
- W2067382092 cites W2067971485 @default.
- W2067382092 cites W2069527370 @default.