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- W2067386688 abstract "To examine the influence of maternal lymphocyte factors on the immune responses in offspring in early life, antibody production in neonates born to either normal or lymphocyte-deficient mothers was analyzed. Recombination activating gene (Rag)-2+/− mouse neonates born to Rag-2+/+, Rag-2+/−or Rag-2−/−mothers were injected with goat anti-mouse IgD antiserum, and IgE and IgG1 production was evaluated. The levels of IgE and IgG1 were higher in the pups born to Rag-2+/+and Rag-2+/− dams than to lymphocyte-deficient Rag-2−/− dams. The enhanced antibody production in the former compared with the latter neonates was also found following immunization with ovalbumin or TNP-Ficoll. Thus, the presence of maternal lymphocyte factors was suggested in neonates that augmented antigen-specific antibody production in both T cell-dependent and -independent pathways. A reduction in antibody production was observed in normal neonates when they were foster-nursed by Rag-2−/− mothers. Thus, the maternal lymphocyte factors enhancing the immune responses in newborns were shown to be present in breast-milk." @default.
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- W2067386688 date "2003-01-01" @default.
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- W2067386688 title "Antibody production in early life supported by maternal lymphocyte factors" @default.
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- W2067386688 doi "https://doi.org/10.1016/s0925-4439(02)00211-9" @default.
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