FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2067395158> ?p ?o ?g. }

• W2067395158 endingPage "534" @default.
• W2067395158 startingPage "529" @default.
• W2067395158 abstract "This study investigated the usefulness of 99mTc hydrazinonicotinamide-galactosylated chitosan (HGC) in hepatocyte imaging. HGC was obtained by coupling the galactose moiety of both lactobionic acid and succinimidyl 6-hydrazinonicotinate hydrochloride (succinimidyl HYNIC). The coupled product was then radiolabeled with 99mTc using stannous chloride and tricine as reducing agent and coligand, respectively. Labeling efficiency was >90% both in room temperature and in serum up to 24 h after injection. The hepatic uptake properties of 99mTc HGC were studied in Balb/C mice. 99mTc HGC and 99mTc hydrazinonicotinamide chitosan (HC) were intravenously injected into mice, with receptor binding identified by coinjection with 9 and 14 mg of free galactose. Images were acquired with a γ-camera. After injection via the tail vein of the mice, 99mTc HGC showed high selectivity for the liver, while 99mTc HC without a galactose group showed low liver uptake. In addition, the hepatic uptake of 99mTc HGC was blocked by coinjection of free galactose. Tissue distribution was determined at three different times (10, 60 and 120 min). The liver accumulated 13.16±2.72%, 16.11±5.70% and 16.55±2.28% of the injected dose per gram at 10, 60 and 120 min after injection, respectively. 99mTc HGC showed specific and rapid targeting of hepatocytes. It is a promising receptor-specific radiopharmaceutical with potential applications in liver imaging for the evaluation of hepatocytic function." @default.
• W2067395158 created "2016-06-24" @default.
• W2067395158 creator A5001737851 @default.
• W2067395158 creator A5006720579 @default.
• W2067395158 creator A5011091703 @default.
• W2067395158 creator A5017366073 @default.
• W2067395158 creator A5034815628 @default.
• W2067395158 creator A5053995401 @default.
• W2067395158 creator A5079729400 @default.
• W2067395158 creator A5082078967 @default.
• W2067395158 date "2006-05-01" @default.
• W2067395158 modified "2023-09-24" @default.
• W2067395158 title "Asialoglycoprotein-receptor-targeted hepatocyte imaging using 99mTc galactosylated chitosan" @default.
• W2067395158 cites W1551383822 @default.
• W2067395158 cites W1567882028 @default.
• W2067395158 cites W1974533156 @default.
• W2067395158 cites W1983855812 @default.
• W2067395158 cites W1984014884 @default.
• W2067395158 cites W1986353574 @default.
• W2067395158 cites W2015080610 @default.
• W2067395158 cites W2064184046 @default.
• W2067395158 cites W2076351150 @default.
• W2067395158 cites W2107355828 @default.
• W2067395158 doi "https://doi.org/10.1016/j.nucmedbio.2006.03.005" @default.
• W2067395158 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16720245" @default.
• W2067395158 hasPublicationYear "2006" @default.
• W2067395158 type Work @default.
• W2067395158 sameAs 2067395158 @default.
• W2067395158 citedByCount "60" @default.
• W2067395158 countsByYear W20673951582012 @default.
• W2067395158 countsByYear W20673951582013 @default.
• W2067395158 countsByYear W20673951582014 @default.
• W2067395158 countsByYear W20673951582015 @default.
• W2067395158 countsByYear W20673951582016 @default.
• W2067395158 countsByYear W20673951582017 @default.
• W2067395158 countsByYear W20673951582018 @default.
• W2067395158 countsByYear W20673951582019 @default.
• W2067395158 countsByYear W20673951582020 @default.
• W2067395158 countsByYear W20673951582021 @default.
• W2067395158 countsByYear W20673951582022 @default.
• W2067395158 crossrefType "journal-article" @default.
• W2067395158 hasAuthorship W2067395158A5001737851 @default.
• W2067395158 hasAuthorship W2067395158A5006720579 @default.
• W2067395158 hasAuthorship W2067395158A5011091703 @default.
• W2067395158 hasAuthorship W2067395158A5017366073 @default.
• W2067395158 hasAuthorship W2067395158A5034815628 @default.
• W2067395158 hasAuthorship W2067395158A5053995401 @default.
• W2067395158 hasAuthorship W2067395158A5079729400 @default.
• W2067395158 hasAuthorship W2067395158A5082078967 @default.
• W2067395158 hasConcept C11569505 @default.
• W2067395158 hasConcept C150903083 @default.
• W2067395158 hasConcept C170493617 @default.
• W2067395158 hasConcept C185592680 @default.
• W2067395158 hasConcept C202751555 @default.
• W2067395158 hasConcept C207001950 @default.
• W2067395158 hasConcept C2776200302 @default.
• W2067395158 hasConcept C2776568683 @default.
• W2067395158 hasConcept C2777807558 @default.
• W2067395158 hasConcept C2778172261 @default.
• W2067395158 hasConcept C2778173381 @default.
• W2067395158 hasConcept C2779732960 @default.
• W2067395158 hasConcept C55493867 @default.
• W2067395158 hasConcept C71240020 @default.
• W2067395158 hasConcept C86803240 @default.
• W2067395158 hasConceptScore W2067395158C11569505 @default.
• W2067395158 hasConceptScore W2067395158C150903083 @default.
• W2067395158 hasConceptScore W2067395158C170493617 @default.
• W2067395158 hasConceptScore W2067395158C185592680 @default.
• W2067395158 hasConceptScore W2067395158C202751555 @default.
• W2067395158 hasConceptScore W2067395158C207001950 @default.
• W2067395158 hasConceptScore W2067395158C2776200302 @default.
• W2067395158 hasConceptScore W2067395158C2776568683 @default.
• W2067395158 hasConceptScore W2067395158C2777807558 @default.
• W2067395158 hasConceptScore W2067395158C2778172261 @default.
• W2067395158 hasConceptScore W2067395158C2778173381 @default.
• W2067395158 hasConceptScore W2067395158C2779732960 @default.
• W2067395158 hasConceptScore W2067395158C55493867 @default.
• W2067395158 hasConceptScore W2067395158C71240020 @default.
• W2067395158 hasConceptScore W2067395158C86803240 @default.
• W2067395158 hasIssue "4" @default.
• W2067395158 hasLocation W20673951581 @default.
• W2067395158 hasLocation W20673951582 @default.
• W2067395158 hasOpenAccess W2067395158 @default.
• W2067395158 hasPrimaryLocation W20673951581 @default.
• W2067395158 hasRelatedWork W1590418081 @default.
• W2067395158 hasRelatedWork W1980074822 @default.
• W2067395158 hasRelatedWork W2067395158 @default.
• W2067395158 hasRelatedWork W2078183180 @default.
• W2067395158 hasRelatedWork W2093281717 @default.
• W2067395158 hasRelatedWork W2139146726 @default.
• W2067395158 hasRelatedWork W2271745928 @default.
• W2067395158 hasRelatedWork W2401958400 @default.
• W2067395158 hasRelatedWork W3034335471 @default.
• W2067395158 hasRelatedWork W2140966208 @default.
• W2067395158 hasVolume "33" @default.
• W2067395158 isParatext "false" @default.
• W2067395158 isRetracted "false" @default.
• W2067395158 magId "2067395158" @default.

• next