Matches in SemOpenAlex for { <https://semopenalex.org/work/W2067396914> ?p ?o ?g. }
- W2067396914 endingPage "783" @default.
- W2067396914 startingPage "774" @default.
- W2067396914 abstract "Radiation is used in the study of neurogenesis in the adult mouse both as a model for patients undergoing radiation therapy for CNS malignancies and as a tool to interrupt neurogenesis. We describe the use of a dedicated CT-guided precision device to irradiate specific sub-regions of the adult mouse brain. Improved CT visualization was accomplished with intrathecal injection of iodinated contrast agent, which enhances the lateral ventricles. T2-weighted MRI images were also used for target localization. Visualization of delivered beams (10 Gy) in tissue was accomplished with immunohistochemical staining for the protein γ-H2AX, a marker of DNA double-strand breaks. γ-H2AX stains showed that the lateral ventricle wall could be targeted with an accuracy of 0.19 mm (n = 10). In the hippocampus, γ-H2AX staining showed that the dentate gyrus can be irradiated unilaterally with a localized arc treatment. This resulted in a significant decrease of proliferative neural progenitor cells as measured by Ki-67 staining (P < 0.001) while leaving the contralateral side intact. Two months after localized irradiation, neurogenesis was significantly inhibited in the irradiated region as seen with EdU/NeuN double labeling (P < 0.001). Localized radiation in the rodent brain is a promising new tool for the study of neurogenesis." @default.
- W2067396914 created "2016-06-24" @default.
- W2067396914 creator A5009183873 @default.
- W2067396914 creator A5011806472 @default.
- W2067396914 creator A5015023507 @default.
- W2067396914 creator A5027386504 @default.
- W2067396914 creator A5028917512 @default.
- W2067396914 creator A5029294194 @default.
- W2067396914 creator A5031746784 @default.
- W2067396914 creator A5031778103 @default.
- W2067396914 creator A5033231728 @default.
- W2067396914 creator A5035595903 @default.
- W2067396914 creator A5038087509 @default.
- W2067396914 creator A5045832666 @default.
- W2067396914 creator A5075369502 @default.
- W2067396914 date "2011-06-01" @default.
- W2067396914 modified "2023-09-27" @default.
- W2067396914 title "Localized CT-Guided Irradiation Inhibits Neurogenesis in Specific Regions of the Adult Mouse Brain" @default.
- W2067396914 cites W1487852103 @default.
- W2067396914 cites W1772265277 @default.
- W2067396914 cites W1964317792 @default.
- W2067396914 cites W1964413769 @default.
- W2067396914 cites W1972194998 @default.
- W2067396914 cites W1976118071 @default.
- W2067396914 cites W1977979138 @default.
- W2067396914 cites W1980940171 @default.
- W2067396914 cites W1982528484 @default.
- W2067396914 cites W1983793855 @default.
- W2067396914 cites W1983955843 @default.
- W2067396914 cites W1990646544 @default.
- W2067396914 cites W1990981339 @default.
- W2067396914 cites W1992106925 @default.
- W2067396914 cites W2001973174 @default.
- W2067396914 cites W2003935374 @default.
- W2067396914 cites W2007242343 @default.
- W2067396914 cites W2009246149 @default.
- W2067396914 cites W2025604203 @default.
- W2067396914 cites W2030442090 @default.
- W2067396914 cites W2041986914 @default.
- W2067396914 cites W2044890358 @default.
- W2067396914 cites W2054121698 @default.
- W2067396914 cites W2054643626 @default.
- W2067396914 cites W2055301723 @default.
- W2067396914 cites W2057377682 @default.
- W2067396914 cites W2060073184 @default.
- W2067396914 cites W2064994363 @default.
- W2067396914 cites W2070794162 @default.
- W2067396914 cites W2071181288 @default.
- W2067396914 cites W2073005183 @default.
- W2067396914 cites W2075175820 @default.
- W2067396914 cites W2077265387 @default.
- W2067396914 cites W2078977128 @default.
- W2067396914 cites W2083743152 @default.
- W2067396914 cites W2085408461 @default.
- W2067396914 cites W2086266995 @default.
- W2067396914 cites W2089388002 @default.
- W2067396914 cites W2092245844 @default.
- W2067396914 cites W2098137179 @default.
- W2067396914 cites W2099250398 @default.
- W2067396914 cites W2108461283 @default.
- W2067396914 cites W2113120301 @default.
- W2067396914 cites W2117248906 @default.
- W2067396914 cites W2117506912 @default.
- W2067396914 cites W2121009504 @default.
- W2067396914 cites W2130923780 @default.
- W2067396914 cites W2131453056 @default.
- W2067396914 cites W2134325392 @default.
- W2067396914 cites W2139481908 @default.
- W2067396914 cites W2145884075 @default.
- W2067396914 cites W2148239264 @default.
- W2067396914 cites W2151400960 @default.
- W2067396914 cites W2153122353 @default.
- W2067396914 cites W2156802639 @default.
- W2067396914 cites W2157615237 @default.
- W2067396914 cites W2166029424 @default.
- W2067396914 cites W2168367012 @default.
- W2067396914 doi "https://doi.org/10.1667/rr2214.1" @default.
- W2067396914 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3142866" @default.
- W2067396914 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21449714" @default.
- W2067396914 hasPublicationYear "2011" @default.
- W2067396914 type Work @default.
- W2067396914 sameAs 2067396914 @default.
- W2067396914 citedByCount "51" @default.
- W2067396914 countsByYear W20673969142012 @default.
- W2067396914 countsByYear W20673969142013 @default.
- W2067396914 countsByYear W20673969142014 @default.
- W2067396914 countsByYear W20673969142015 @default.
- W2067396914 countsByYear W20673969142016 @default.
- W2067396914 countsByYear W20673969142017 @default.
- W2067396914 countsByYear W20673969142018 @default.
- W2067396914 countsByYear W20673969142019 @default.
- W2067396914 countsByYear W20673969142020 @default.
- W2067396914 countsByYear W20673969142021 @default.
- W2067396914 countsByYear W20673969142022 @default.
- W2067396914 countsByYear W20673969142023 @default.
- W2067396914 crossrefType "journal-article" @default.
- W2067396914 hasAuthorship W2067396914A5009183873 @default.
- W2067396914 hasAuthorship W2067396914A5011806472 @default.