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• W2067400935 startingPage "4942" @default.
• W2067400935 abstract "The epithelium to mesenchyme transition is thought to play a fundamental role during embryonic development and tumor progression. Loss of cell–cell adhesion and modification of both cell morphology and gene expression are the main events associated with this transition. There is a large amount of evidence suggesting that growth factors can initiate these events. Yet, the connection from growth factor induction to changes in cell adhesion and morphology is largely unknown. To elucidate this connection, we have investigated the action of IGF-II on E-cadherin/β-catenin complex-mediated cell–cell adhesion and on β-catenin/TCF-3 mediated gene expression. We can show that (1) IGF-II induces a rapid epithelium to mesenchymal transition; (2) IGF1R, the receptor for IGF-II, belongs to the same membrane complex as E-cadherin and β-catenin; (3) IGF-II induces a redistribution of β-catenin from the plasma membrane to the nucleus and an intracellular sequestration and degradation of E-cadherin; (4) IGF-II induces the transcription of β-catenin/TCF-3 target genes. Based on the given case of IGF-II and E-cadherin/β-catenin complex, this study reveals the backbone of a cascade connecting growth factor signaling with cell–cell adhesion during EMT." @default.
• W2067400935 created "2016-06-24" @default.
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• W2067400935 date "2001-08-16" @default.
• W2067400935 modified "2023-10-17" @default.
• W2067400935 title "IGF-II induces rapid β-catenin relocation to the nucleus during epithelium to mesenchyme transition" @default.
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• W2067400935 doi "https://doi.org/10.1038/sj.onc.1204660" @default.
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• W2067400935 hasPublicationYear "2001" @default.
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