FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2067401023> ?p ?o ?g. }

• W2067401023 endingPage "371" @default.
• W2067401023 startingPage "362" @default.
• W2067401023 abstract "Abstract: Several clinicopathologic variables influence prognosis in breast cancer, including stage, histologic grade, nodal status, and tumor size. Multiple studies have shown an independent value of proliferation index as a prognostic variable for the stratification into favorable and unfavorable groups. The monoclonal antibody MIB-1 reacts with the same antigen site, not epitope, as recognized by the Ki-67 antibody. Like Ki-67, MIB-1 reacts with cells in the late G1, S, M and G2 phases of the cell cycle, but MIB-1 has the advantage of reacting with formalin-fixed, paraffin-embedded material. The authors investigated the feasibility of using image analysis to quantitate the MIB-1 antibody staining (proliferation index [PI]) and predict survival in a series of 230 patients with stage I and stage II breast cancer. In a univariate Cox regression model, larger values of MIB-1 were related to shorter survival times (p < 0.001). Exploratory statistical procedures were used to categorize the patients into good, intermediate, and poor survival groups using the following proliferation indices as cut-points: <5%, 5–11%, and >11 %, respectively. Higher clinical stage was associated with higher MIB-1 values and shorter survival (p = 0.01, and p = 0.003, respectively). Tumor size (p = 0.02) and nodal status (p = 0.05) were also associated with higher values of MIB-1. After adjusting for age, clinical stage, nodal status, and tumor size in a multivariate analysis, MIB-1 retained its prognostic significance (p < 0.0001) when considered as either a continuous or categorical variable. There were no significant associations between MIB-1 determined proliferation index and age (p = 0.54), histologic grade (p = 0.69), nuclear grade (p = 0.06) or the presence of vascular invasion (p =.66). There is a strong statistical relationship between cell proliferative activity, as determined by MIB-1 expression, and survival in early stage breast cancer." @default.
• W2067401023 created "2016-06-24" @default.
• W2067401023 creator A5032566475 @default.
• W2067401023 creator A5033280911 @default.
• W2067401023 creator A5054646389 @default.
• W2067401023 creator A5060835997 @default.
• W2067401023 creator A5068672834 @default.
• W2067401023 creator A5072814489 @default.
• W2067401023 date "1995-11-01" @default.
• W2067401023 modified "2023-10-16" @default.
• W2067401023 title "Determination of Proliferation Index By MIB-1 Immunostaining in Early Stage Breast Cancer Using Quantitative Image Analysis" @default.
• W2067401023 cites W1971199765 @default.
• W2067401023 cites W1987622162 @default.
• W2067401023 cites W1998080624 @default.
• W2067401023 cites W1998110577 @default.
• W2067401023 cites W2001804802 @default.
• W2067401023 cites W2022207305 @default.
• W2067401023 cites W2026250491 @default.
• W2067401023 cites W2029912336 @default.
• W2067401023 cites W2032772058 @default.
• W2067401023 cites W2038166181 @default.
• W2067401023 cites W2043979480 @default.
• W2067401023 cites W2047203335 @default.
• W2067401023 cites W2052565867 @default.
• W2067401023 cites W2057572282 @default.
• W2067401023 cites W2066772641 @default.
• W2067401023 cites W2079644951 @default.
• W2067401023 cites W2080663008 @default.
• W2067401023 cites W2083072213 @default.
• W2067401023 cites W2126486896 @default.
• W2067401023 cites W2154094995 @default.
• W2067401023 cites W2154536753 @default.
• W2067401023 cites W2163299027 @default.
• W2067401023 cites W2230285032 @default.
• W2067401023 cites W2316053901 @default.
• W2067401023 cites W2330872152 @default.
• W2067401023 cites W2438321957 @default.
• W2067401023 cites W267005183 @default.
• W2067401023 cites W3041047318 @default.
• W2067401023 cites W4237576626 @default.
• W2067401023 doi "https://doi.org/10.1111/j.1524-4741.1995.tb00263.x" @default.
• W2067401023 hasPublicationYear "1995" @default.
• W2067401023 type Work @default.
• W2067401023 sameAs 2067401023 @default.
• W2067401023 citedByCount "6" @default.
• W2067401023 crossrefType "journal-article" @default.
• W2067401023 hasAuthorship W2067401023A5032566475 @default.
• W2067401023 hasAuthorship W2067401023A5033280911 @default.
• W2067401023 hasAuthorship W2067401023A5054646389 @default.
• W2067401023 hasAuthorship W2067401023A5060835997 @default.
• W2067401023 hasAuthorship W2067401023A5068672834 @default.
• W2067401023 hasAuthorship W2067401023A5072814489 @default.
• W2067401023 hasBestOaLocation W20674010231 @default.
• W2067401023 hasConcept C105795698 @default.
• W2067401023 hasConcept C121608353 @default.
• W2067401023 hasConcept C126322002 @default.
• W2067401023 hasConcept C142724271 @default.
• W2067401023 hasConcept C143998085 @default.
• W2067401023 hasConcept C144301174 @default.
• W2067401023 hasConcept C146357865 @default.
• W2067401023 hasConcept C151730666 @default.
• W2067401023 hasConcept C159654299 @default.
• W2067401023 hasConcept C161584116 @default.
• W2067401023 hasConcept C199163554 @default.
• W2067401023 hasConcept C203014093 @default.
• W2067401023 hasConcept C204232928 @default.
• W2067401023 hasConcept C2776085573 @default.
• W2067401023 hasConcept C2910938049 @default.
• W2067401023 hasConcept C33923547 @default.
• W2067401023 hasConcept C38180746 @default.
• W2067401023 hasConcept C4224716 @default.
• W2067401023 hasConcept C50382708 @default.
• W2067401023 hasConcept C530470458 @default.
• W2067401023 hasConcept C542903549 @default.
• W2067401023 hasConcept C71924100 @default.
• W2067401023 hasConcept C86803240 @default.
• W2067401023 hasConceptScore W2067401023C105795698 @default.
• W2067401023 hasConceptScore W2067401023C121608353 @default.
• W2067401023 hasConceptScore W2067401023C126322002 @default.
• W2067401023 hasConceptScore W2067401023C142724271 @default.
• W2067401023 hasConceptScore W2067401023C143998085 @default.
• W2067401023 hasConceptScore W2067401023C144301174 @default.
• W2067401023 hasConceptScore W2067401023C146357865 @default.
• W2067401023 hasConceptScore W2067401023C151730666 @default.
• W2067401023 hasConceptScore W2067401023C159654299 @default.
• W2067401023 hasConceptScore W2067401023C161584116 @default.
• W2067401023 hasConceptScore W2067401023C199163554 @default.
• W2067401023 hasConceptScore W2067401023C203014093 @default.
• W2067401023 hasConceptScore W2067401023C204232928 @default.
• W2067401023 hasConceptScore W2067401023C2776085573 @default.
• W2067401023 hasConceptScore W2067401023C2910938049 @default.
• W2067401023 hasConceptScore W2067401023C33923547 @default.
• W2067401023 hasConceptScore W2067401023C38180746 @default.
• W2067401023 hasConceptScore W2067401023C4224716 @default.
• W2067401023 hasConceptScore W2067401023C50382708 @default.
• W2067401023 hasConceptScore W2067401023C530470458 @default.
• W2067401023 hasConceptScore W2067401023C542903549 @default.
• W2067401023 hasConceptScore W2067401023C71924100 @default.

• next