FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2067407535> ?p ?o ?g. }

• W2067407535 endingPage "290" @default.
• W2067407535 startingPage "287" @default.
• W2067407535 abstract "In order to investigate the regulation of presynaptic phospholipase D (PLD) activity by calcium and G proteins, we established a permeabilization procedure for rat cortical synaptosomes using Staphylococcus aureus α‐toxin (30–100 μg/ml). In permeabilized synaptosomes, PLD activity was significantly stimulated when the concentration of free calcium was increased from 0.1 μM to 1 μM. This activation was inhibited in the presence of KN‐62 (1 μM), an inhibitor of calcium/calmodulin‐dependent kinase II (CaMKII), but not by the protein kinase C inhibitor, Ro 31‐8220 (1–10 μM). Synaptosomal PLD activity was also stimulated in the presence of 1 μM GTPγS. When Rho proteins were inhibited by pretreatment of the synaptosomes with Clostridium difficile toxin B (TcdB; 1–10 ng/ml), the effect of GTPγS was significantly reduced; in contrast, brefeldin A (10–100 μM), an inhibitor of ARF activation, was ineffective. Calcium stimulation of PLD was inhibited by TcdB, but GTPγS‐dependent activation was insensitive to KN‐62. We conclude that synaptosomal PLD is activated in a pathway which sequentially involves CaMKII and Rho proteins." @default.
• W2067407535 created "2016-06-24" @default.
• W2067407535 creator A5016757927 @default.
• W2067407535 creator A5027941021 @default.
• W2067407535 creator A5031282807 @default.
• W2067407535 creator A5032970473 @default.
• W2067407535 creator A5054866144 @default.
• W2067407535 creator A5085441376 @default.
• W2067407535 creator A5087065860 @default.
• W2067407535 date "1998-12-04" @default.
• W2067407535 modified "2023-10-14" @default.
• W2067407535 title "Regulation of phospholipase D activity in synaptosomes permeabilized with<i>Staphylococcus aureus</i>α-toxin" @default.
• W2067407535 cites W1526510974 @default.
• W2067407535 cites W1561066485 @default.
• W2067407535 cites W1594827149 @default.
• W2067407535 cites W1599213556 @default.
• W2067407535 cites W1973624256 @default.
• W2067407535 cites W1976695667 @default.
• W2067407535 cites W1982619523 @default.
• W2067407535 cites W1982807202 @default.
• W2067407535 cites W1984152194 @default.
• W2067407535 cites W2018640222 @default.
• W2067407535 cites W2019420003 @default.
• W2067407535 cites W2033954573 @default.
• W2067407535 cites W2050621406 @default.
• W2067407535 cites W2085825273 @default.
• W2067407535 cites W2093101675 @default.
• W2067407535 cites W2094612853 @default.
• W2067407535 cites W2112919363 @default.
• W2067407535 cites W2153444523 @default.
• W2067407535 cites W2156967607 @default.
• W2067407535 cites W59209658 @default.
• W2067407535 doi "https://doi.org/10.1016/s0014-5793(98)01479-3" @default.
• W2067407535 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9872388" @default.
• W2067407535 hasPublicationYear "1998" @default.
• W2067407535 type Work @default.
• W2067407535 sameAs 2067407535 @default.
• W2067407535 citedByCount "19" @default.
• W2067407535 countsByYear W20674075352012 @default.
• W2067407535 countsByYear W20674075352013 @default.
• W2067407535 countsByYear W20674075352014 @default.
• W2067407535 countsByYear W20674075352016 @default.
• W2067407535 countsByYear W20674075352017 @default.
• W2067407535 countsByYear W20674075352023 @default.
• W2067407535 crossrefType "journal-article" @default.
• W2067407535 hasAuthorship W2067407535A5016757927 @default.
• W2067407535 hasAuthorship W2067407535A5027941021 @default.
• W2067407535 hasAuthorship W2067407535A5031282807 @default.
• W2067407535 hasAuthorship W2067407535A5032970473 @default.
• W2067407535 hasAuthorship W2067407535A5054866144 @default.
• W2067407535 hasAuthorship W2067407535A5085441376 @default.
• W2067407535 hasAuthorship W2067407535A5087065860 @default.
• W2067407535 hasBestOaLocation W20674075351 @default.
• W2067407535 hasConcept C118716 @default.
• W2067407535 hasConcept C12927208 @default.
• W2067407535 hasConcept C134193097 @default.
• W2067407535 hasConcept C178790620 @default.
• W2067407535 hasConcept C181199279 @default.
• W2067407535 hasConcept C185592680 @default.
• W2067407535 hasConcept C195794163 @default.
• W2067407535 hasConcept C202751555 @default.
• W2067407535 hasConcept C2777367657 @default.
• W2067407535 hasConcept C2778597717 @default.
• W2067407535 hasConcept C2778921374 @default.
• W2067407535 hasConcept C2779489039 @default.
• W2067407535 hasConcept C29688787 @default.
• W2067407535 hasConcept C2994496256 @default.
• W2067407535 hasConcept C501593827 @default.
• W2067407535 hasConcept C519063684 @default.
• W2067407535 hasConcept C523546767 @default.
• W2067407535 hasConcept C54355233 @default.
• W2067407535 hasConcept C55493867 @default.
• W2067407535 hasConcept C6182249 @default.
• W2067407535 hasConcept C62478195 @default.
• W2067407535 hasConcept C80631254 @default.
• W2067407535 hasConcept C86803240 @default.
• W2067407535 hasConcept C97505648 @default.
• W2067407535 hasConceptScore W2067407535C118716 @default.
• W2067407535 hasConceptScore W2067407535C12927208 @default.
• W2067407535 hasConceptScore W2067407535C134193097 @default.
• W2067407535 hasConceptScore W2067407535C178790620 @default.
• W2067407535 hasConceptScore W2067407535C181199279 @default.
• W2067407535 hasConceptScore W2067407535C185592680 @default.
• W2067407535 hasConceptScore W2067407535C195794163 @default.
• W2067407535 hasConceptScore W2067407535C202751555 @default.
• W2067407535 hasConceptScore W2067407535C2777367657 @default.
• W2067407535 hasConceptScore W2067407535C2778597717 @default.
• W2067407535 hasConceptScore W2067407535C2778921374 @default.
• W2067407535 hasConceptScore W2067407535C2779489039 @default.
• W2067407535 hasConceptScore W2067407535C29688787 @default.
• W2067407535 hasConceptScore W2067407535C2994496256 @default.
• W2067407535 hasConceptScore W2067407535C501593827 @default.
• W2067407535 hasConceptScore W2067407535C519063684 @default.
• W2067407535 hasConceptScore W2067407535C523546767 @default.
• W2067407535 hasConceptScore W2067407535C54355233 @default.
• W2067407535 hasConceptScore W2067407535C55493867 @default.
• W2067407535 hasConceptScore W2067407535C6182249 @default.
• W2067407535 hasConceptScore W2067407535C62478195 @default.

• next