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• W2067416738 abstract "During our on-going studies to identify bioactive compounds in medicinal herbs, we found that saucerneol F (SF), a naturally occurring sesquilignan isolated from Saururus chinensis (S. chinensis), showed in vitro anti-inflammatory activity. In this study, we examined the effects of SF on the generation of 5-lipoxygenase (5-LO) dependent leukotriene <TEX>$C_4$</TEX> (<TEX>$LTC_4$</TEX>), cyclooxygenase-2 (COX-2) dependent prostaglandin <TEX>$D_2$</TEX> (<TEX>$PGD_2$</TEX>), and on phospholipase <TEX>$C{gamma}1$</TEX> (<TEX>$PLC{gamma}1$</TEX>)-mediated degranulation in SCF-induced mouse bone marrow-derived mast cells (BMMCs). SF inhibited eicosanoid (<TEX>$PGD_2$</TEX> and <TEX>$LTC_4$</TEX>) generation and degranulation dose-dependently. To identify the molecular mechanisms underlying the inhibition of eicosanoid generation and degranulation by SF, we examined the effects of SF on the phosphorylation of <TEX>$PLC{gamma}1$</TEX>, intracellular <TEX>$Ca^{2+}$</TEX> influx, the translocation of cytosolic phospholipase <TEX>$A_2$</TEX> (<TEX>$cPLA_2$</TEX>) and 5-LO, and on the phosphorylation of MAP kinases (MAPKs). SF was found to reduce intracellular <TEX>$Ca^{2+}$</TEX> influx by inhibiting <TEX>$PLC{gamma}1$</TEX> phosphorylation and suppressing the nuclear translocations of <TEX>$cPLA_2$</TEX> and 5-LO via the phosphorylations of MAPKs, including extracellular signal-regulated protein kinase-1/2 (ERK1/2), c-Jun N-terminal kinase (JNK), and p38. Taken together, these results suggest that SF may be useful for regulating mast cell-mediated inflammatory responses by inhibiting degranulation and eicosanoid generation." @default.
• W2067416738 created "2016-06-24" @default.
• W2067416738 creator A5042439874 @default.
• W2067416738 creator A5054654340 @default.
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• W2067416738 date "2012-11-30" @default.
• W2067416738 modified "2023-09-30" @default.
• W2067416738 title "Saucerneol F, a New Lignan Isolated from Saururus chinensis, Attenuates Degranulation via Phospholipase Cγ1 Inhibition and Eicosanoid Generation by Suppressing MAP Kinases in Mast Cells" @default.
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• W2067416738 doi "https://doi.org/10.4062/biomolther.2012.20.6.526" @default.
• W2067416738 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3762291" @default.
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