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- W2067419983 abstract "A diffusion-reaction, two-compartment model was used to explore thebifurcation and chaotic behavior of acetylcholinesterase (AChE) andcholineacetyltransferase (ChAT) coupled enzymes system. The effects of hydrogenion feed concentrations, choline (Ch) and acetylcholine (ACh) feedconcentrations, as bifurcation parameters on the system performance arestudied. It is found that hydrogen ions play an important role in creatingpotential differences through the plasma membranes. Detailed bifurcationanalysis over a wide range of parameters is carried out in order to uncoversome of the qualitative changes of the system such as hysteresis, multiplicity,Hopf bifurcation, boundary crises bifurcation, periodic transient, and othercomplex dynamics. Some of the obtained results relate to the phenomenaoccurring in the physiological experiments like periodic stimulation of neuralcells and irregular functioning of acetylcholine receptors. The model dependson real kinetics expressions and parameters obtained from the literature, sothe results can be used to direct more systematic research on cholinergicdisorder." @default.
- W2067419983 created "2016-06-24" @default.
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- W2067419983 date "2013-01-01" @default.
- W2067419983 modified "2023-09-27" @default.
- W2067419983 title "Bifurcation Analysis of a Coupled Acetylcholinesterase/Choline Acetyltransferase Enzymes Neurocycle" @default.
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- W2067419983 doi "https://doi.org/10.4236/aces.2013.31003" @default.
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