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- W2067422016 abstract "In cultured fibroblasts of adrenoleukodystrophy (ALD) patients and most heterozygotes, concentrations of long-chain fatty acids (> C22) were significantly higher than in controls when cells were assayed 45 days after reaching confluence. Intermediate values were found in three independent cultures of a girl with manifest ALD, suggesting that a significant proportion of her fibroblasts does not express the defect. Though long-chain fatty acid concentrations in heterozygotes were somewhat higher than expected, suggesting a slight preponderance of defective cells, it may be too early to conclude that somatic selection is a consistent finding in cultured fibroblasts of ALD carriers." @default.
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- W2067422016 date "2008-04-23" @default.
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- W2067422016 title "Adrenoleukodystrophy: diagnosis and carrier detection by determination of long-chain fatty acids in cultured fibroblasts" @default.
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- W2067422016 doi "https://doi.org/10.1111/j.1399-0004.1982.tb01406.x" @default.
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