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• W2067430888 abstract "The mechanisms of an increase in cytosolic Ca2+ concentration ([Ca2+]i) due to the removal of extracellular cations were examined using the whole-cell patch-clamp technique in combination with fura-2 microfluorometry in guinea pig adrenal chromaffin cells. Removal of Ca2+ and Mg2+ from sucrose-substituted Na+-free solution (0Ca, 0Mg-sucrose) evoked an increase in [Ca2+]i that was suppressed by the addition of Ca2+, Mg2+ or EGTA extracellularly. When Na+ was replaced by Tris+, NMDG+, Li+, Cs+ or choline+, no comparable increase in [Ca2+]i was evoked in the absence of external Ca2+. In voltage-clamped cells at −60 mV with K+-internal solution, 0Ca, 0Mg-sucrose evoked a transient [Ca2+]i increase concomitant with an outward current. In Cs+-loaded cells, 0Ca, 0Mg-sucrose caused a marked inward current (Iin) accompanied by an increase of [Ca2+]i. Choline+-substituted solution produced only a brief Iin without any increase of [Ca2+]i. Both Iin and [Ca2+]i responses to 0Ca, 0Mg-sucrose occurred with holding potentials more positive than −65 mV. The increase in [Ca2+]i expected from the time-integrated Iin evoked by 0Ca, 0Mg-sucrose was correlated with that in [Ca2+]i measured with fura-2. A voltage-dependent Ca2+ channel (VDC) blocker reversibly suppressed the Iin and [Ca2+]i responses to 0Ca, 0Mg-sucrose. Cyclopiazonic acid, an internal store-emptying agent, did not affect both current and [Ca2+]i responses to 0Ca, 0Mg-sucrose. Brief exposure to external EGTA greatly reduced these responses, suggesting that Ca2+ near and/or bound to the cell membrane plays a role in 0Ca, 0Mg-sucrose-induced responses. In sucrose-substituted solution, current–voltage relations for VDC were shifted to negative potentials by decreasing the external Ca2+. These results suggest that VDC activation, probably due to the change in the surface potentials on the gating mechanism of VDC, is involved in the elevation of [Ca2+]i induced by deprivation of divalent cations from sucrose substituted Na+-free solution in adrenal chromaffin cells." @default.
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• W2067430888 date "1998-12-01" @default.
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• W2067430888 title "Involvement of voltage-dependent Ca2+ channels in cytosolic Ca2+ increase induced by deprivation of extracellular cations in adrenal chromaffin cells of the guinea pig" @default.
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• W2067430888 doi "https://doi.org/10.1016/s0006-8993(98)01038-5" @default.
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