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• W2067431283 endingPage "825" @default.
• W2067431283 startingPage "815" @default.
• W2067431283 abstract "DAUGÉ, V. AND I. LÉNA. CCK in anxiety and cognitive processes. NEUROSCI BIOBEHAV REV 22(6) 815–825, 1998.—Extensive studies were carried out on the involvement of the CCKergic system in anxiety-, panic- and stress-related behaviour. The stimulation of CCK-A or CCK-B receptors is implicated in the physical and psychological responses of CCK to stress. Furthermore, several selective CCK-B agonists produce anxiogenic-like effects, while CCK-B antagonists induce anxiolytic-like responses in several models of anxiety. However, BC264 a highly selective CCK-B agonist, does not produce anxiogenic-like effects but increases attention and/or memory. These effects are dependent on the dopaminergic systems. Together with biochemical data, this led to the hypothesis of the existence of two CCK-B binding sites, CCK-B1 and CCK-B2, which could correspond to different activation states of a single molecular entity. Investigations into CCK-B1 and CCK-B2 systems might be of critical interest, since only one site, CCK-B1, appears to be responsible for the effects on anxiety. Furthermore, the improvement of attention and/or memory processes by CCK, through CCK-B2 receptors, could offer a new perspective in the treatment of attention and/or memory disorders." @default.
• W2067431283 created "2016-06-24" @default.
• W2067431283 creator A5020457094 @default.
• W2067431283 creator A5066614625 @default.
• W2067431283 date "1998-10-01" @default.
• W2067431283 modified "2023-10-18" @default.
• W2067431283 title "CCK in Anxiety and Cognitive Processes" @default.
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