Matches in SemOpenAlex for { <https://semopenalex.org/work/W2067438475> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2067438475 endingPage "34" @default.
- W2067438475 startingPage "31" @default.
- W2067438475 abstract "The worsening shortage of cadaver donor kidneys has prompted use of expanded or marginal donor kidneys (MDK), i.e. older age or donor history of hypertension or diabetes. MDK may be especially susceptible to calcineurin-inhibitor (CI) mediated vasoconstriction and nephrotoxicity. Similarly, early use of CI in patients with delayed graft function may prolong ischaemic injury. We developed a CI-free protocol of antibody induction, sirolimus, mycophenolate mofetil, and prednisone in recipients with MDK or DGF.Adult renal transplant recipients who received MDK or had DGF were treated with a CI-free protocol consisting of antibody induction (basiliximab or thymoglobulin), sirolimus, mycophenolate mofetil, and prednisone. Serial biopsies were performed for persistent DGF. Patients were followed prospectively with the primary endpoints being patient and graft survival, biopsy-proven acute rejection, and sirolimus-related toxicity.Nineteen recipients were treated. Mean follow-up was 294 days. Actuarial 6- and 12-month patient survival was 100% and 100% and graft survival was 93% and 93%, respectively. The only graft loss was due to primary non-function (PNF). The incidence of AR was 16%. Mean serum creatinine at last follow-up was 1.6 mg/dL. Sirolimus-related toxicity included lymphocele (1), wound infection (2), thrombocytopenia (1). and interstitial pneumonitis (1).A CI-free protocol with antibody induction and sirolimus results in low rates of AR and PNF and excellent early patient and graft survival in patients with MDK and DGF. CI-free protocols may allow expansion of the kidney donor pool by encouraging utilization of MDK at high risk for DGF or CI-mediated nephrotoxicity." @default.
- W2067438475 created "2016-06-24" @default.
- W2067438475 creator A5021967365 @default.
- W2067438475 creator A5022010691 @default.
- W2067438475 creator A5049342396 @default.
- W2067438475 creator A5055433546 @default.
- W2067438475 creator A5080208809 @default.
- W2067438475 creator A5087596222 @default.
- W2067438475 date "2003-06-01" @default.
- W2067438475 modified "2023-10-16" @default.
- W2067438475 title "A pilot protocol of a calcineurin-inhibitor free regimen for kidney transplant recipients of marginal donor kidneys or with delayed graft function" @default.
- W2067438475 cites W1967792664 @default.
- W2067438475 cites W2018100390 @default.
- W2067438475 cites W2023201732 @default.
- W2067438475 cites W2123036912 @default.
- W2067438475 cites W2123720448 @default.
- W2067438475 cites W2123940335 @default.
- W2067438475 cites W68282923 @default.
- W2067438475 doi "https://doi.org/10.1034/j.1399-0012.17.s9.5.x" @default.
- W2067438475 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12795665" @default.
- W2067438475 hasPublicationYear "2003" @default.
- W2067438475 type Work @default.
- W2067438475 sameAs 2067438475 @default.
- W2067438475 citedByCount "46" @default.
- W2067438475 countsByYear W20674384752012 @default.
- W2067438475 countsByYear W20674384752014 @default.
- W2067438475 countsByYear W20674384752015 @default.
- W2067438475 countsByYear W20674384752016 @default.
- W2067438475 countsByYear W20674384752017 @default.
- W2067438475 countsByYear W20674384752018 @default.
- W2067438475 countsByYear W20674384752020 @default.
- W2067438475 crossrefType "journal-article" @default.
- W2067438475 hasAuthorship W2067438475A5021967365 @default.
- W2067438475 hasAuthorship W2067438475A5022010691 @default.
- W2067438475 hasAuthorship W2067438475A5049342396 @default.
- W2067438475 hasAuthorship W2067438475A5055433546 @default.
- W2067438475 hasAuthorship W2067438475A5080208809 @default.
- W2067438475 hasAuthorship W2067438475A5087596222 @default.
- W2067438475 hasBestOaLocation W20674384751 @default.
- W2067438475 hasConcept C126322002 @default.
- W2067438475 hasConcept C126894567 @default.
- W2067438475 hasConcept C128057223 @default.
- W2067438475 hasConcept C141071460 @default.
- W2067438475 hasConcept C2777630719 @default.
- W2067438475 hasConcept C2777921159 @default.
- W2067438475 hasConcept C2778033501 @default.
- W2067438475 hasConcept C2778720950 @default.
- W2067438475 hasConcept C2780303639 @default.
- W2067438475 hasConcept C2781307858 @default.
- W2067438475 hasConcept C2911091166 @default.
- W2067438475 hasConcept C64518967 @default.
- W2067438475 hasConcept C71924100 @default.
- W2067438475 hasConceptScore W2067438475C126322002 @default.
- W2067438475 hasConceptScore W2067438475C126894567 @default.
- W2067438475 hasConceptScore W2067438475C128057223 @default.
- W2067438475 hasConceptScore W2067438475C141071460 @default.
- W2067438475 hasConceptScore W2067438475C2777630719 @default.
- W2067438475 hasConceptScore W2067438475C2777921159 @default.
- W2067438475 hasConceptScore W2067438475C2778033501 @default.
- W2067438475 hasConceptScore W2067438475C2778720950 @default.
- W2067438475 hasConceptScore W2067438475C2780303639 @default.
- W2067438475 hasConceptScore W2067438475C2781307858 @default.
- W2067438475 hasConceptScore W2067438475C2911091166 @default.
- W2067438475 hasConceptScore W2067438475C64518967 @default.
- W2067438475 hasConceptScore W2067438475C71924100 @default.
- W2067438475 hasLocation W20674384751 @default.
- W2067438475 hasLocation W20674384752 @default.
- W2067438475 hasOpenAccess W2067438475 @default.
- W2067438475 hasPrimaryLocation W20674384751 @default.
- W2067438475 hasRelatedWork W1823521930 @default.
- W2067438475 hasRelatedWork W1969318433 @default.
- W2067438475 hasRelatedWork W2020405446 @default.
- W2067438475 hasRelatedWork W2024905006 @default.
- W2067438475 hasRelatedWork W2057773251 @default.
- W2067438475 hasRelatedWork W2067438475 @default.
- W2067438475 hasRelatedWork W2072583817 @default.
- W2067438475 hasRelatedWork W2120961905 @default.
- W2067438475 hasRelatedWork W2964380494 @default.
- W2067438475 hasRelatedWork W4240284178 @default.
- W2067438475 hasVolume "17" @default.
- W2067438475 isParatext "false" @default.
- W2067438475 isRetracted "false" @default.
- W2067438475 magId "2067438475" @default.
- W2067438475 workType "article" @default.