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• W2067441729 abstract "We investigated the radiolabeling efficiency, in vitro stability, and biodistribution of radioactive iodine (131I)-labeled 4-benzoyl-1-(4-carboxyphenyl)-5-phenyl-1H-pyrazole-3-carboxylic acid (P3CA). A quality-control study of the labeled substance (131I-P3CA) was conducted using electrophoresis and radio thin-layer chromatography (RTLC). Biodistribution studies were undertaken in 9 female albino Wistar rats. Rats were killed at various times (15, 60 and 180 min), their organs removed, and percentage of injected dose per gram (ID%/g) values calculated. The labeling yield of P3CA was 97.08%±0.80%. The maximum uptake of 131I-P3CA was seen in the lungs, stomach and spleen at 15 min. The uptake of labeled compound decreased over time in the lungs, whereas that in the stomach decreased. These data suggest that 131I-P3CA had high binding efficiency, high uptake in the lung, and sufficient stability to be used in diagnostic studies." @default.
• W2067441729 created "2016-06-24" @default.
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• W2067441729 date "2013-05-18" @default.
• W2067441729 modified "2023-10-18" @default.
• W2067441729 title "Labelling of a pyrazole derivative with 131I and investigation of its radiopharmaceutical potential" @default.
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• W2067441729 doi "https://doi.org/10.1007/s11434-013-5832-0" @default.
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