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- W2067447790 abstract "The constraints on nucleotide sequences of highly and weakly expressed genes from Escherichia coli have been analysed and compared. Differences in synonymous codon spectra in highly and weakly expressed genes lead to different frequencies of nucleotides (in the first and third codon positions) and dinucleotides in the two groups of genes. It has been found that the choice of synonymous codons in highly expressed genes depends on the nucleotides adjacent to the codon. For example, lysine is preferably encoded by the AAA codon if guanosine is 3′ to the lysine codon (AAA-G, P < 10−9). And, on the contrary, AAG is used more often than AAA (P < 0.001) if cytidine is 3′ adjacent to lysine. Guanosine occurs more frequently than adenosine 5′ to all the lysine codons (AAR, P < 10−5), i.e. NNG codons are preferred over the synonymous NNA codons 5′ to the positions of lysine in the genes. The context effect was observed in nonsense and missense suppression experiments. Therefore, a hypothesis has been suggested that the efficiency of translation of some codons (for which the constraints on the adjacent nucleotides were found) can be modulated by the codon context. The rules for preferable synonymous codon choice in highly expressed genes depending on the nucleotides surrounding the codon are presented. These rules can be used in the chemical synthesis of genes designed for expression in E. coli." @default.
- W2067447790 created "2016-06-24" @default.
- W2067447790 creator A5049908244 @default.
- W2067447790 date "1986-04-01" @default.
- W2067447790 modified "2023-09-27" @default.
- W2067447790 title "Constraints on codon context in Escherichia coli genes their possible role in modulating the efficiency of translation" @default.
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- W2067447790 doi "https://doi.org/10.1016/s0022-2836(86)80005-5" @default.
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