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- W2067450395 abstract "Abstract Apolipoprotein E (apoE) is an important protein involved in lipoprotein clearance and cholesterol redistribution. ApoE is abundantly expressed in astrocytes in the brain and is closely linked to the pathogenesis of Alzheimer's disease (AD). We report here that small molecule ligands that activate either liver X receptors (LXR) or retinoid X receptor (RXR) lead to a dramatic increase in apoE mRNA and protein expression as well as secretion of apoE in a human astrocytoma cell line (CCF‐STTG1 cells). Examination of primary mouse astrocytes also revealed significant induction of apoE mRNA, and protein expression and secretion following incubation with LXR/RXR agonists. Moreover, treatment of mice with a specific synthetic LXR agonist T0901317 resulted in up‐regulation of apoE mRNA and protein in both hippocampus and cerebral cortex, indicating that apoE expression in brain can be up‐regulated by LXR agonists in vivo . Along with a dramatic induction of ABCA1 cholesterol transporter expression, these ligands effectively mediate cholesterol efflux in both CCF‐STTG1 cells and mouse astrocytes in the presence or absence of apolipoprotein AI (apoAI). Our studies provide strong evidence that small molecule LXR/RXR agonists can effectively mediate apoE synthesis and secretion as well as cholesterol homeostasis in astrocytes. LXR/RXR agonists may have significant impact on the pathogenesis of multiple neurological diseases, including AD." @default.
- W2067450395 created "2016-06-24" @default.
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- W2067450395 date "2004-01-13" @default.
- W2067450395 modified "2023-10-12" @default.
- W2067450395 title "A liver X receptor and retinoid X receptor heterodimer mediates apolipoprotein E expression, secretion and cholesterol homeostasis in astrocytes" @default.
- W2067450395 cites W1570388980 @default.
- W2067450395 cites W1585393120 @default.
- W2067450395 cites W1588900436 @default.
- W2067450395 cites W1591670239 @default.
- W2067450395 cites W1604658771 @default.
- W2067450395 cites W1607230014 @default.
- W2067450395 cites W1607399348 @default.
- W2067450395 cites W170055736 @default.
- W2067450395 cites W1860908381 @default.
- W2067450395 cites W1962935964 @default.
- W2067450395 cites W1965050626 @default.
- W2067450395 cites W1970761589 @default.
- W2067450395 cites W1972960247 @default.
- W2067450395 cites W1980352486 @default.
- W2067450395 cites W1980940682 @default.
- W2067450395 cites W1981554609 @default.
- W2067450395 cites W1985859760 @default.
- W2067450395 cites W1986439388 @default.
- W2067450395 cites W1992653391 @default.
- W2067450395 cites W1993629125 @default.
- W2067450395 cites W1993668532 @default.
- W2067450395 cites W1995754186 @default.
- W2067450395 cites W1996168740 @default.
- W2067450395 cites W1997913988 @default.
- W2067450395 cites W2001332055 @default.
- W2067450395 cites W2003798182 @default.
- W2067450395 cites W2006409771 @default.
- W2067450395 cites W2007929153 @default.
- W2067450395 cites W2009111659 @default.
- W2067450395 cites W2010390315 @default.
- W2067450395 cites W2024851295 @default.
- W2067450395 cites W2028841673 @default.
- W2067450395 cites W2032513433 @default.
- W2067450395 cites W2034280067 @default.
- W2067450395 cites W2034968148 @default.
- W2067450395 cites W2035883738 @default.
- W2067450395 cites W2040417680 @default.
- W2067450395 cites W2041994355 @default.
- W2067450395 cites W2046165699 @default.
- W2067450395 cites W2047397116 @default.
- W2067450395 cites W2054059991 @default.
- W2067450395 cites W2054099490 @default.
- W2067450395 cites W2056800449 @default.
- W2067450395 cites W2063968666 @default.
- W2067450395 cites W2067064610 @default.
- W2067450395 cites W2076819195 @default.
- W2067450395 cites W2080305329 @default.
- W2067450395 cites W2081722421 @default.
- W2067450395 cites W2082336678 @default.
- W2067450395 cites W2086317930 @default.
- W2067450395 cites W2087083058 @default.
- W2067450395 cites W2088436733 @default.
- W2067450395 cites W2090966154 @default.
- W2067450395 cites W2095424587 @default.
- W2067450395 cites W2096410114 @default.
- W2067450395 cites W2098460507 @default.
- W2067450395 cites W2101077392 @default.
- W2067450395 cites W2115309238 @default.
- W2067450395 cites W2116824509 @default.
- W2067450395 cites W2119556701 @default.
- W2067450395 cites W2128565374 @default.
- W2067450395 cites W2130092916 @default.
- W2067450395 cites W2133025814 @default.
- W2067450395 cites W2133182306 @default.
- W2067450395 cites W2136421145 @default.
- W2067450395 cites W2138955227 @default.
- W2067450395 cites W2147321151 @default.
- W2067450395 cites W2147413218 @default.
- W2067450395 cites W2152192643 @default.
- W2067450395 cites W2153673003 @default.
- W2067450395 cites W2154206390 @default.
- W2067450395 cites W2163481458 @default.
- W2067450395 cites W2169359444 @default.
- W2067450395 cites W2185058201 @default.
- W2067450395 cites W4230088158 @default.
- W2067450395 cites W72978219 @default.
- W2067450395 doi "https://doi.org/10.1111/j.1471-4159.2004.02183.x" @default.
- W2067450395 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14720212" @default.
- W2067450395 hasPublicationYear "2004" @default.
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