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- W2067470897 abstract "The impact of dry eye disease on patient’s health, visual function and quality of life may be substantial. At present, the only approved pharmacological treatment in the U.S. or Canada is Restasis® (cyclosporine ophthalmic emulsion). In Japan, three products are approved: Hyalein® (hyaluronic acid), Diquas® (diquafasol), and Mucosta® (rebamapide). No pharmacological treatment is currently approved in Europe. In this article, I will provide updates on “new” pharmacological treatments—i.e., those beyond any approved as of January 2012, primarily those in clinical trials. Novel treatment for pharmacological management of dry eye disease is an area of active clinical development as evidenced by numerous recently completed or ongoing studies. The pharmacological agents in evaluation cover a wide range of putative mechanisms of action. However, firms developing these agents continue to be challenged by the limitations of animal models of efficacy, relatively small and variable clinical effects in Phase 2, and the investment in time and resources required for Phase 3." @default.
- W2067470897 created "2016-06-24" @default.
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- W2067470897 date "2013-03-06" @default.
- W2067470897 modified "2023-09-23" @default.
- W2067470897 title "New Pharmacological Treatments for Dry Eye Disease" @default.
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- W2067470897 doi "https://doi.org/10.1007/s40135-013-0007-3" @default.
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