FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2067473453> ?p ?o ?g. }

• W2067473453 abstract "Renin, a major regulatory component of the renin-angiotensin system, plays a pivotal role in regulating blood pressure and electrolyte homeostasis and is predominantly expressed in the kidney. Several cAMP-responsive elements have been identified within renin gene promoters. Here, we study how 2 such elements, renin proximal promoter element-2 (RP-2) and overlapping cAMP and negative regulatory elements (CNRE), affect the transcriptional regulation of renin. We generated Tg mice (TgM) bearing BACs containing either WT or mutant RP-2 or CNRE, integrated at single chromosomal loci. Analysis of the TgM revealed that RP-2 was essential to basal promoter activity in the kidney, while renin mRNA levels did not significantly change in any tissues tested in the CNRE mutant TgM. To evaluate the physiological significance of these mutations, we used the BAC Tg to rescue hypotensive Renin-null mutant mice. As predicted, no renin expression was observed in the kidneys of RP-2 mutant/Renin-null compound mice, whereas renin expression in CNRE mutant compound mice was indistinguishable from that in control mice. Consistent with this, RP-2 mutant animals were hypotensive, while CNRE mutants had normal blood pressure. Thus, transcriptional regulation of renin expression via RP-2 but not CNRE is critical for blood pressure regulation by this gene." @default.
• W2067473453 created "2016-06-24" @default.
• W2067473453 creator A5019990741 @default.
• W2067473453 creator A5027395239 @default.
• W2067473453 creator A5038746129 @default.
• W2067473453 creator A5047879551 @default.
• W2067473453 creator A5063610442 @default.
• W2067473453 creator A5064930879 @default.
• W2067473453 creator A5072842770 @default.
• W2067473453 date "2008-02-01" @default.
• W2067473453 modified "2023-09-25" @default.
• W2067473453 title "A single nucleotide mutation in the mouse renin promoter disrupts blood pressure regulation" @default.
• W2067473453 cites W1505231237 @default.
• W2067473453 cites W1518308338 @default.
• W2067473453 cites W1537498059 @default.
• W2067473453 cites W1546796591 @default.
• W2067473453 cites W1580418149 @default.
• W2067473453 cites W1903692288 @default.
• W2067473453 cites W1964864779 @default.
• W2067473453 cites W1979055697 @default.
• W2067473453 cites W1990181136 @default.
• W2067473453 cites W1991078847 @default.
• W2067473453 cites W1992304926 @default.
• W2067473453 cites W2000496244 @default.
• W2067473453 cites W2003306808 @default.
• W2067473453 cites W2007609806 @default.
• W2067473453 cites W2008205503 @default.
• W2067473453 cites W2017651478 @default.
• W2067473453 cites W2033662757 @default.
• W2067473453 cites W2041279525 @default.
• W2067473453 cites W2042008154 @default.
• W2067473453 cites W2049889066 @default.
• W2067473453 cites W2052280873 @default.
• W2067473453 cites W2058024551 @default.
• W2067473453 cites W2081391060 @default.
• W2067473453 cites W2093548319 @default.
• W2067473453 cites W2094853557 @default.
• W2067473453 cites W2102430393 @default.
• W2067473453 cites W2108928055 @default.
• W2067473453 cites W2114286710 @default.
• W2067473453 cites W2123404816 @default.
• W2067473453 cites W2123958263 @default.
• W2067473453 cites W2125198125 @default.
• W2067473453 cites W2126690315 @default.
• W2067473453 cites W2137291142 @default.
• W2067473453 cites W2140796853 @default.
• W2067473453 cites W2141655045 @default.
• W2067473453 cites W2145445649 @default.
• W2067473453 cites W2150012285 @default.
• W2067473453 cites W2163634050 @default.
• W2067473453 cites W2167297838 @default.
• W2067473453 cites W2168400074 @default.
• W2067473453 cites W2225667633 @default.
• W2067473453 doi "https://doi.org/10.1172/jci33824" @default.
• W2067473453 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2230662" @default.
• W2067473453 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18259612" @default.
• W2067473453 hasPublicationYear "2008" @default.
• W2067473453 type Work @default.
• W2067473453 sameAs 2067473453 @default.
• W2067473453 citedByCount "8" @default.
• W2067473453 countsByYear W20674734532013 @default.
• W2067473453 countsByYear W20674734532015 @default.
• W2067473453 countsByYear W20674734532016 @default.
• W2067473453 countsByYear W20674734532017 @default.
• W2067473453 countsByYear W20674734532018 @default.
• W2067473453 crossrefType "journal-article" @default.
• W2067473453 hasAuthorship W2067473453A5019990741 @default.
• W2067473453 hasAuthorship W2067473453A5027395239 @default.
• W2067473453 hasAuthorship W2067473453A5038746129 @default.
• W2067473453 hasAuthorship W2067473453A5047879551 @default.
• W2067473453 hasAuthorship W2067473453A5063610442 @default.
• W2067473453 hasAuthorship W2067473453A5064930879 @default.
• W2067473453 hasAuthorship W2067473453A5072842770 @default.
• W2067473453 hasBestOaLocation W20674734531 @default.
• W2067473453 hasConcept C104317684 @default.
• W2067473453 hasConcept C105580179 @default.
• W2067473453 hasConcept C126322002 @default.
• W2067473453 hasConcept C134018914 @default.
• W2067473453 hasConcept C143065580 @default.
• W2067473453 hasConcept C150194340 @default.
• W2067473453 hasConcept C153911025 @default.
• W2067473453 hasConcept C165864922 @default.
• W2067473453 hasConcept C198710026 @default.
• W2067473453 hasConcept C2780091579 @default.
• W2067473453 hasConcept C501734568 @default.
• W2067473453 hasConcept C54355233 @default.
• W2067473453 hasConcept C63645605 @default.
• W2067473453 hasConcept C71924100 @default.
• W2067473453 hasConcept C84393581 @default.
• W2067473453 hasConcept C86803240 @default.
• W2067473453 hasConceptScore W2067473453C104317684 @default.
• W2067473453 hasConceptScore W2067473453C105580179 @default.
• W2067473453 hasConceptScore W2067473453C126322002 @default.
• W2067473453 hasConceptScore W2067473453C134018914 @default.
• W2067473453 hasConceptScore W2067473453C143065580 @default.
• W2067473453 hasConceptScore W2067473453C150194340 @default.
• W2067473453 hasConceptScore W2067473453C153911025 @default.
• W2067473453 hasConceptScore W2067473453C165864922 @default.
• W2067473453 hasConceptScore W2067473453C198710026 @default.
• W2067473453 hasConceptScore W2067473453C2780091579 @default.

• next