FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2067473500> ?p ?o ?g. }

• W2067473500 endingPage "379" @default.
• W2067473500 startingPage "372" @default.
• W2067473500 abstract "Several animal studies suggested that the angiotensin II type 2 (AT2) receptor subtype mediates vasodilation, yet the results in human arteries are less well described and more inconsistent. Therefore, we evaluated the role of the AT2 receptor stimulation on the vasotonus of human internal mammary arteries.Internal mammary arteries were obtained from 50 patients undergoing coronary bypass surgery. The expression of angiotensin II type 1 (AT1) receptor and AT2 receptor mRNA was determined by using real-time polymerase chain reaction. In addition, angiotensin II and CGP42112A concentration-response curves (concentration range: 10(-10) M to 10(-6) M) were constructed in absence or presence of candesartan (10(-5) M) and/or the AT2 receptor-antagonist PD-123319 (10(-6) M) and/or the alpha receptor antagonist phentolamine.Both AT1 and AT2 receptor protein and mRNA were detected, and higher AT2 receptor mRNA expression levels were associated with increased contractile response to angiotensin II. Angiotensin II caused vasoconstriction up to 41.1 +/- 6.5% of the maximal response to phenylephrine, and PD123319 significantly reduced this response (28.6 +/- 9.6%, P < 0.001). Candesartan completely blocked the angiotensin II-mediated response (1.4 +/- 3.1%, P < 0.001 versus control), and additional blockade of the AT2 receptor with PD123319 did not change this effect (1.8 +/- 5.1%). Phentolamine (10(-5) M) caused attenuation and rightward shift of the angiotensin II concentration response curves. The AT2 receptor agonist CGP42112A did not induce a significant response.Although AT2 receptor mRNA is present in human internal mammary arteries, AT2 receptor stimulation does not mediate vasodilation in these arteries." @default.
• W2067473500 created "2016-06-24" @default.
• W2067473500 creator A5003503629 @default.
• W2067473500 creator A5005468364 @default.
• W2067473500 creator A5005643821 @default.
• W2067473500 creator A5008177500 @default.
• W2067473500 creator A5018149893 @default.
• W2067473500 creator A5029075021 @default.
• W2067473500 creator A5038443503 @default.
• W2067473500 creator A5043667469 @default.
• W2067473500 creator A5046228917 @default.
• W2067473500 creator A5079571445 @default.
• W2067473500 creator A5085204166 @default.
• W2067473500 date "2007-10-01" @default.
• W2067473500 modified "2023-09-27" @default.
• W2067473500 title "Angiotensin II Type 2 Receptor Vasoactivity in Internal Mammary Arteries of Patients With Coronary Artery Disease" @default.
• W2067473500 cites W1963827482 @default.
• W2067473500 cites W1971911190 @default.
• W2067473500 cites W1973257819 @default.
• W2067473500 cites W1974814786 @default.
• W2067473500 cites W1975728250 @default.
• W2067473500 cites W1978902219 @default.
• W2067473500 cites W1990461933 @default.
• W2067473500 cites W1997932090 @default.
• W2067473500 cites W2004761146 @default.
• W2067473500 cites W2017800047 @default.
• W2067473500 cites W2020815929 @default.
• W2067473500 cites W2054359587 @default.
• W2067473500 cites W2060681074 @default.
• W2067473500 cites W2074289890 @default.
• W2067473500 cites W2074404219 @default.
• W2067473500 cites W2082542825 @default.
• W2067473500 cites W2097489256 @default.
• W2067473500 cites W2106070854 @default.
• W2067473500 cites W2123841491 @default.
• W2067473500 cites W2131304527 @default.
• W2067473500 cites W2131438048 @default.
• W2067473500 cites W2133534620 @default.
• W2067473500 cites W2141059150 @default.
• W2067473500 cites W2149743327 @default.
• W2067473500 cites W2149868661 @default.
• W2067473500 cites W2166253620 @default.
• W2067473500 cites W2170047585 @default.
• W2067473500 doi "https://doi.org/10.1097/fjc.0b013e31811ea222" @default.
• W2067473500 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18049304" @default.
• W2067473500 hasPublicationYear "2007" @default.
• W2067473500 type Work @default.
• W2067473500 sameAs 2067473500 @default.
• W2067473500 citedByCount "11" @default.
• W2067473500 countsByYear W20674735002012 @default.
• W2067473500 countsByYear W20674735002013 @default.
• W2067473500 countsByYear W20674735002014 @default.
• W2067473500 countsByYear W20674735002015 @default.
• W2067473500 countsByYear W20674735002022 @default.
• W2067473500 crossrefType "journal-article" @default.
• W2067473500 hasAuthorship W2067473500A5003503629 @default.
• W2067473500 hasAuthorship W2067473500A5005468364 @default.
• W2067473500 hasAuthorship W2067473500A5005643821 @default.
• W2067473500 hasAuthorship W2067473500A5008177500 @default.
• W2067473500 hasAuthorship W2067473500A5018149893 @default.
• W2067473500 hasAuthorship W2067473500A5029075021 @default.
• W2067473500 hasAuthorship W2067473500A5038443503 @default.
• W2067473500 hasAuthorship W2067473500A5043667469 @default.
• W2067473500 hasAuthorship W2067473500A5046228917 @default.
• W2067473500 hasAuthorship W2067473500A5079571445 @default.
• W2067473500 hasAuthorship W2067473500A5085204166 @default.
• W2067473500 hasBestOaLocation W20674735001 @default.
• W2067473500 hasConcept C104849204 @default.
• W2067473500 hasConcept C120770815 @default.
• W2067473500 hasConcept C123915805 @default.
• W2067473500 hasConcept C126322002 @default.
• W2067473500 hasConcept C134018914 @default.
• W2067473500 hasConcept C170493617 @default.
• W2067473500 hasConcept C185592680 @default.
• W2067473500 hasConcept C198710026 @default.
• W2067473500 hasConcept C2776885963 @default.
• W2067473500 hasConcept C2777952589 @default.
• W2067473500 hasConcept C2778122271 @default.
• W2067473500 hasConcept C2779961880 @default.
• W2067473500 hasConcept C2780036600 @default.
• W2067473500 hasConcept C2780253649 @default.
• W2067473500 hasConcept C2908929049 @default.
• W2067473500 hasConcept C71924100 @default.
• W2067473500 hasConcept C84393581 @default.
• W2067473500 hasConceptScore W2067473500C104849204 @default.
• W2067473500 hasConceptScore W2067473500C120770815 @default.
• W2067473500 hasConceptScore W2067473500C123915805 @default.
• W2067473500 hasConceptScore W2067473500C126322002 @default.
• W2067473500 hasConceptScore W2067473500C134018914 @default.
• W2067473500 hasConceptScore W2067473500C170493617 @default.
• W2067473500 hasConceptScore W2067473500C185592680 @default.
• W2067473500 hasConceptScore W2067473500C198710026 @default.
• W2067473500 hasConceptScore W2067473500C2776885963 @default.
• W2067473500 hasConceptScore W2067473500C2777952589 @default.
• W2067473500 hasConceptScore W2067473500C2778122271 @default.
• W2067473500 hasConceptScore W2067473500C2779961880 @default.
• W2067473500 hasConceptScore W2067473500C2780036600 @default.
• W2067473500 hasConceptScore W2067473500C2780253649 @default.

• next