Matches in SemOpenAlex for { <https://semopenalex.org/work/W2067474009> ?p ?o ?g. }
- W2067474009 endingPage "41" @default.
- W2067474009 startingPage "34" @default.
- W2067474009 abstract "The protective effect of 7-O-galloyl-D-sedoheptulose (GS), isolated from Corni Fructus as an active component, against acute renal failure (ARF) induced by glycerol was investigated. The administration of GS led to a decline in the levels of blood urea nitrogen and creatinine; on the other hand, it did not have a significant effect on creatinine clearance. Furthermore, GS also significantly decreased the urine volume and fractional excretion of sodium, but it increased the urine osmolarity, suggesting the protective role of GS against renal dysfunction. Oxidative stress under ARF was attenuated by GS through the inhibition of lipid peroxidation, scavenging of reactive oxygen species (ROS), and elevation of the antioxidative status. Renal oxidative stress is related to the overproduction of ROS by nicotinamide adenine dinucleotide phosphate (NAD(P)H) oxidase; therefore, in the present study, the protein expression of p22(phox) and NAD(P)H oxidase-4 (Nox-4) was investigated. GS down-regulated the protein expression of p22(phox); on the other hand, it did not significantly affect the expression of Nox-4. This indicates that GS inhibits the production of superoxide by regulating a component of NAD(P)H oxidase, p22(phox). Furthermore, GS down-regulated the expressions of nuclear factor-κB (NF-κΒ) and inducible nitric oxide (NO) synthase (iNOS), suggesting that GS protects against NO-induced inflammatory pathological conditions under ARF through the regulation of NF-κB and iNOS expressions. The present study indicates that GS exerts a protective effect against ARF through the recovery of renal dysfunction and attenuation of renal oxidative stress by regulating related protein expression." @default.
- W2067474009 created "2016-06-24" @default.
- W2067474009 creator A5018799075 @default.
- W2067474009 creator A5020503634 @default.
- W2067474009 creator A5032849986 @default.
- W2067474009 creator A5034786651 @default.
- W2067474009 creator A5072697111 @default.
- W2067474009 creator A5088189689 @default.
- W2067474009 date "2012-01-01" @default.
- W2067474009 modified "2023-10-01" @default.
- W2067474009 title "Glycerol-Induced Renal Damage Improved by 7-O-Galloyl-D-sedoheptulose Treatment through Attenuating Oxidative Stress" @default.
- W2067474009 cites W1842360996 @default.
- W2067474009 cites W1975680536 @default.
- W2067474009 cites W1978490997 @default.
- W2067474009 cites W1981426346 @default.
- W2067474009 cites W1993691280 @default.
- W2067474009 cites W1995396825 @default.
- W2067474009 cites W1999810991 @default.
- W2067474009 cites W2001106994 @default.
- W2067474009 cites W2001117353 @default.
- W2067474009 cites W2006140590 @default.
- W2067474009 cites W2016821346 @default.
- W2067474009 cites W2023411279 @default.
- W2067474009 cites W2026261400 @default.
- W2067474009 cites W2026297158 @default.
- W2067474009 cites W2027354071 @default.
- W2067474009 cites W2053054955 @default.
- W2067474009 cites W2054825442 @default.
- W2067474009 cites W2064487623 @default.
- W2067474009 cites W2073769825 @default.
- W2067474009 cites W2078349619 @default.
- W2067474009 cites W2081731746 @default.
- W2067474009 cites W2088204476 @default.
- W2067474009 cites W2092463788 @default.
- W2067474009 cites W2095761135 @default.
- W2067474009 cites W2103277769 @default.
- W2067474009 cites W2104507412 @default.
- W2067474009 cites W2105779843 @default.
- W2067474009 cites W2108927222 @default.
- W2067474009 cites W2111632121 @default.
- W2067474009 cites W2132199758 @default.
- W2067474009 cites W2135087363 @default.
- W2067474009 cites W2138503494 @default.
- W2067474009 cites W2140660632 @default.
- W2067474009 cites W2150449873 @default.
- W2067474009 cites W2164932836 @default.
- W2067474009 cites W2203098242 @default.
- W2067474009 cites W2281653534 @default.
- W2067474009 cites W40189241 @default.
- W2067474009 cites W4246889888 @default.
- W2067474009 doi "https://doi.org/10.1248/bpb.35.34" @default.
- W2067474009 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22223334" @default.
- W2067474009 hasPublicationYear "2012" @default.
- W2067474009 type Work @default.
- W2067474009 sameAs 2067474009 @default.
- W2067474009 citedByCount "26" @default.
- W2067474009 countsByYear W20674740092014 @default.
- W2067474009 countsByYear W20674740092015 @default.
- W2067474009 countsByYear W20674740092016 @default.
- W2067474009 countsByYear W20674740092017 @default.
- W2067474009 countsByYear W20674740092018 @default.
- W2067474009 countsByYear W20674740092019 @default.
- W2067474009 countsByYear W20674740092020 @default.
- W2067474009 countsByYear W20674740092021 @default.
- W2067474009 countsByYear W20674740092022 @default.
- W2067474009 countsByYear W20674740092023 @default.
- W2067474009 crossrefType "journal-article" @default.
- W2067474009 hasAuthorship W2067474009A5018799075 @default.
- W2067474009 hasAuthorship W2067474009A5020503634 @default.
- W2067474009 hasAuthorship W2067474009A5032849986 @default.
- W2067474009 hasAuthorship W2067474009A5034786651 @default.
- W2067474009 hasAuthorship W2067474009A5072697111 @default.
- W2067474009 hasAuthorship W2067474009A5088189689 @default.
- W2067474009 hasBestOaLocation W20674740091 @default.
- W2067474009 hasConcept C126322002 @default.
- W2067474009 hasConcept C134018914 @default.
- W2067474009 hasConcept C178790620 @default.
- W2067474009 hasConcept C181199279 @default.
- W2067474009 hasConcept C185592680 @default.
- W2067474009 hasConcept C2775838275 @default.
- W2067474009 hasConcept C2776151105 @default.
- W2067474009 hasConcept C2776901170 @default.
- W2067474009 hasConcept C2777622882 @default.
- W2067474009 hasConcept C2777989768 @default.
- W2067474009 hasConcept C2779719074 @default.
- W2067474009 hasConcept C2780795997 @default.
- W2067474009 hasConcept C2780829032 @default.
- W2067474009 hasConcept C2781252958 @default.
- W2067474009 hasConcept C38485361 @default.
- W2067474009 hasConcept C48349386 @default.
- W2067474009 hasConcept C519581460 @default.
- W2067474009 hasConcept C55493867 @default.
- W2067474009 hasConcept C71924100 @default.
- W2067474009 hasConcept C75520062 @default.
- W2067474009 hasConcept C86803240 @default.
- W2067474009 hasConcept C98274493 @default.
- W2067474009 hasConceptScore W2067474009C126322002 @default.
- W2067474009 hasConceptScore W2067474009C134018914 @default.