Matches in SemOpenAlex for { <https://semopenalex.org/work/W2067474788> ?p ?o ?g. }
- W2067474788 endingPage "170" @default.
- W2067474788 startingPage "163" @default.
- W2067474788 abstract "The prevalence of type 2 diabetes in Canadian Oji-Cree is among the highest in the world. Our research has uncovered genetic determinants of Oji-Cree type 2 diabetes and related metabolic traits. The most important genetic discovery by far was the private G319S mutation in transcription factor HNF-1α, encoded by the HNF1A gene. HNF1A G319S was discovered by candidate gene sequencing and would have been missed using the currently favored strategy of genome-wide scanning. G319S was associated with increased odds of having type 2 diabetes across the whole study sample and in all subgroups, including adolescent Oji-Cree. Furthermore, G319S had specificity and positive predictive value of 97% and 95%, respectively, for developing type 2 diabetes by age 50. The protein bearing the G319S mutation had impaired function in vitro. Sigmoidal modeling showed that each dose of the G319S allele accelerated the median age of diabetes onset by about 7 yr. This approach also showed that environment more strongly accelerated the median age-of-onset of Oji-Cree diabetes onset than did G319S, which could have implications for intervention strategies to reduce the burden of this epidemic. There is also evidence for genetic determination of related metabolic traits in the Oji-Cree." @default.
- W2067474788 created "2016-06-24" @default.
- W2067474788 creator A5035358062 @default.
- W2067474788 creator A5038040018 @default.
- W2067474788 creator A5055281543 @default.
- W2067474788 creator A5063644691 @default.
- W2067474788 creator A5074159618 @default.
- W2067474788 creator A5090437675 @default.
- W2067474788 date "2003-05-01" @default.
- W2067474788 modified "2023-10-15" @default.
- W2067474788 title "Genes, environment and Oji-Cree type 2 diabetes" @default.
- W2067474788 cites W1569424076 @default.
- W2067474788 cites W1898696587 @default.
- W2067474788 cites W1907998975 @default.
- W2067474788 cites W1918051743 @default.
- W2067474788 cites W1968125565 @default.
- W2067474788 cites W1968759542 @default.
- W2067474788 cites W1972622305 @default.
- W2067474788 cites W1973953801 @default.
- W2067474788 cites W1988092746 @default.
- W2067474788 cites W2002723797 @default.
- W2067474788 cites W2006141697 @default.
- W2067474788 cites W2032744572 @default.
- W2067474788 cites W2033518519 @default.
- W2067474788 cites W2035470883 @default.
- W2067474788 cites W2036696716 @default.
- W2067474788 cites W2044875575 @default.
- W2067474788 cites W2045590599 @default.
- W2067474788 cites W2047150277 @default.
- W2067474788 cites W2047957290 @default.
- W2067474788 cites W2051113703 @default.
- W2067474788 cites W2056868807 @default.
- W2067474788 cites W2059496816 @default.
- W2067474788 cites W2062563019 @default.
- W2067474788 cites W2068006821 @default.
- W2067474788 cites W2071157052 @default.
- W2067474788 cites W2084565301 @default.
- W2067474788 cites W2095346711 @default.
- W2067474788 cites W2097520538 @default.
- W2067474788 cites W2114147184 @default.
- W2067474788 cites W2118344629 @default.
- W2067474788 cites W2124669661 @default.
- W2067474788 cites W2129354714 @default.
- W2067474788 cites W2148409428 @default.
- W2067474788 cites W2153793650 @default.
- W2067474788 cites W2165637855 @default.
- W2067474788 cites W2167055240 @default.
- W2067474788 cites W2169398310 @default.
- W2067474788 cites W2223175061 @default.
- W2067474788 cites W4232326427 @default.
- W2067474788 cites W4235902887 @default.
- W2067474788 cites W4237931064 @default.
- W2067474788 cites W4249128379 @default.
- W2067474788 cites W4252169940 @default.
- W2067474788 cites W4252296800 @default.
- W2067474788 cites W4255088354 @default.
- W2067474788 cites W4299411394 @default.
- W2067474788 doi "https://doi.org/10.1016/s0009-9120(03)00004-3" @default.
- W2067474788 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12726923" @default.
- W2067474788 hasPublicationYear "2003" @default.
- W2067474788 type Work @default.
- W2067474788 sameAs 2067474788 @default.
- W2067474788 citedByCount "48" @default.
- W2067474788 countsByYear W20674747882012 @default.
- W2067474788 countsByYear W20674747882013 @default.
- W2067474788 countsByYear W20674747882014 @default.
- W2067474788 countsByYear W20674747882015 @default.
- W2067474788 countsByYear W20674747882016 @default.
- W2067474788 countsByYear W20674747882018 @default.
- W2067474788 countsByYear W20674747882019 @default.
- W2067474788 countsByYear W20674747882020 @default.
- W2067474788 countsByYear W20674747882022 @default.
- W2067474788 crossrefType "journal-article" @default.
- W2067474788 hasAuthorship W2067474788A5035358062 @default.
- W2067474788 hasAuthorship W2067474788A5038040018 @default.
- W2067474788 hasAuthorship W2067474788A5055281543 @default.
- W2067474788 hasAuthorship W2067474788A5063644691 @default.
- W2067474788 hasAuthorship W2067474788A5074159618 @default.
- W2067474788 hasAuthorship W2067474788A5090437675 @default.
- W2067474788 hasConcept C104317684 @default.
- W2067474788 hasConcept C134018914 @default.
- W2067474788 hasConcept C161600633 @default.
- W2067474788 hasConcept C180754005 @default.
- W2067474788 hasConcept C2777180221 @default.
- W2067474788 hasConcept C54355233 @default.
- W2067474788 hasConcept C555293320 @default.
- W2067474788 hasConcept C69991583 @default.
- W2067474788 hasConcept C71924100 @default.
- W2067474788 hasConcept C86803240 @default.
- W2067474788 hasConceptScore W2067474788C104317684 @default.
- W2067474788 hasConceptScore W2067474788C134018914 @default.
- W2067474788 hasConceptScore W2067474788C161600633 @default.
- W2067474788 hasConceptScore W2067474788C180754005 @default.
- W2067474788 hasConceptScore W2067474788C2777180221 @default.
- W2067474788 hasConceptScore W2067474788C54355233 @default.
- W2067474788 hasConceptScore W2067474788C555293320 @default.
- W2067474788 hasConceptScore W2067474788C69991583 @default.
- W2067474788 hasConceptScore W2067474788C71924100 @default.