FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2067477316> ?p ?o ?g. }

• W2067477316 endingPage "2447" @default.
• W2067477316 startingPage "2443" @default.
• W2067477316 abstract "The symptoms of gallbladder cancer (GBC) are vague and non-specific. Therefore, GBC is often detected at an advanced or metastatic stage. The most effective treatment for GBC is surgical resection, however the majority of GBC cases are unresectable at the time of diagnosis. Therefore, numerous GBC patients undergo chemotherapy. This study reports the case of a 60-year-old female with GBC who underwent successful surgical curative resection following a single dose of the chemotherapeutic agent, S-1, twice daily for 4 weeks followed by a 14-day rest period for 36 months. S-1 is a novel orally administered drug composed of a combination of the 5-fluorouracil (5-FU) prodrug, tegafur, 5-chloro-2,4-dihydroxypyridine (CDHP) and oteracil potassium in a 1:0.4:1 molar concentration ratio. The focus of the present study was the candidate factors that affect the therapeutic efficacy of S-1-based chemotherapy. In particular, the gene expression involved in the S-1 metabolic pathway was investigated by assessing the intratumoral dihydropyrimidine dehydrogenase (DPD), thymidylate synthase (TS) and orotate phosphoribosyltransferase gene expression. The surgical specimen exhibited high intratumoral DPD gene expression levels compared with those observed in previously reported non S-1 responsive cases of biliary tract cancer. Due to the results obtained in the current study, we hypothesize that CDHP enhanced the antitumor efficacy of 5-FU by inhibiting the excess DPD protein produced by the tumor." @default.
• W2067477316 created "2016-06-24" @default.
• W2067477316 creator A5031184711 @default.
• W2067477316 creator A5032206045 @default.
• W2067477316 creator A5036810926 @default.
• W2067477316 creator A5045329864 @default.
• W2067477316 creator A5051945468 @default.
• W2067477316 creator A5063761414 @default.
• W2067477316 creator A5066177154 @default.
• W2067477316 creator A5068363630 @default.
• W2067477316 creator A5087333501 @default.
• W2067477316 creator A5089415177 @default.
• W2067477316 creator A5091036633 @default.
• W2067477316 date "2014-09-26" @default.
• W2067477316 modified "2023-09-28" @default.
• W2067477316 title "Successful curative resection of gallbladder cancer following S-1 chemotherapy: A case report and review of the literature" @default.
• W2067477316 cites W126227279 @default.
• W2067477316 cites W1512786008 @default.
• W2067477316 cites W2001709842 @default.
• W2067477316 cites W2003232455 @default.
• W2067477316 cites W2011815700 @default.
• W2067477316 cites W2023722647 @default.
• W2067477316 cites W2038787775 @default.
• W2067477316 cites W2051224942 @default.
• W2067477316 cites W2067482493 @default.
• W2067477316 cites W2077902459 @default.
• W2067477316 cites W2092747179 @default.
• W2067477316 cites W2108015399 @default.
• W2067477316 cites W2108707912 @default.
• W2067477316 cites W2123928790 @default.
• W2067477316 cites W2128889451 @default.
• W2067477316 cites W2149289168 @default.
• W2067477316 cites W2164411042 @default.
• W2067477316 cites W2170486320 @default.
• W2067477316 cites W2171075804 @default.
• W2067477316 cites W2408948947 @default.
• W2067477316 doi "https://doi.org/10.3892/ol.2014.2565" @default.
• W2067477316 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4214413" @default.
• W2067477316 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25360167" @default.
• W2067477316 hasPublicationYear "2014" @default.
• W2067477316 type Work @default.
• W2067477316 sameAs 2067477316 @default.
• W2067477316 citedByCount "5" @default.
• W2067477316 countsByYear W20674773162015 @default.
• W2067477316 countsByYear W20674773162016 @default.
• W2067477316 countsByYear W20674773162022 @default.
• W2067477316 crossrefType "journal-article" @default.
• W2067477316 hasAuthorship W2067477316A5031184711 @default.
• W2067477316 hasAuthorship W2067477316A5032206045 @default.
• W2067477316 hasAuthorship W2067477316A5036810926 @default.
• W2067477316 hasAuthorship W2067477316A5045329864 @default.
• W2067477316 hasAuthorship W2067477316A5051945468 @default.
• W2067477316 hasAuthorship W2067477316A5063761414 @default.
• W2067477316 hasAuthorship W2067477316A5066177154 @default.
• W2067477316 hasAuthorship W2067477316A5068363630 @default.
• W2067477316 hasAuthorship W2067477316A5087333501 @default.
• W2067477316 hasAuthorship W2067477316A5089415177 @default.
• W2067477316 hasAuthorship W2067477316A5091036633 @default.
• W2067477316 hasBestOaLocation W20674773161 @default.
• W2067477316 hasConcept C108215921 @default.
• W2067477316 hasConcept C121608353 @default.
• W2067477316 hasConcept C123321153 @default.
• W2067477316 hasConcept C126322002 @default.
• W2067477316 hasConcept C143998085 @default.
• W2067477316 hasConcept C2776534502 @default.
• W2067477316 hasConcept C2776694085 @default.
• W2067477316 hasConcept C2777148285 @default.
• W2067477316 hasConcept C2777299880 @default.
• W2067477316 hasConcept C2778050828 @default.
• W2067477316 hasConcept C2780456651 @default.
• W2067477316 hasConcept C2781018059 @default.
• W2067477316 hasConcept C29537977 @default.
• W2067477316 hasConcept C502942594 @default.
• W2067477316 hasConcept C71924100 @default.
• W2067477316 hasConcept C90924648 @default.
• W2067477316 hasConcept C98274493 @default.
• W2067477316 hasConceptScore W2067477316C108215921 @default.
• W2067477316 hasConceptScore W2067477316C121608353 @default.
• W2067477316 hasConceptScore W2067477316C123321153 @default.
• W2067477316 hasConceptScore W2067477316C126322002 @default.
• W2067477316 hasConceptScore W2067477316C143998085 @default.
• W2067477316 hasConceptScore W2067477316C2776534502 @default.
• W2067477316 hasConceptScore W2067477316C2776694085 @default.
• W2067477316 hasConceptScore W2067477316C2777148285 @default.
• W2067477316 hasConceptScore W2067477316C2777299880 @default.
• W2067477316 hasConceptScore W2067477316C2778050828 @default.
• W2067477316 hasConceptScore W2067477316C2780456651 @default.
• W2067477316 hasConceptScore W2067477316C2781018059 @default.
• W2067477316 hasConceptScore W2067477316C29537977 @default.
• W2067477316 hasConceptScore W2067477316C502942594 @default.
• W2067477316 hasConceptScore W2067477316C71924100 @default.
• W2067477316 hasConceptScore W2067477316C90924648 @default.
• W2067477316 hasConceptScore W2067477316C98274493 @default.
• W2067477316 hasIssue "6" @default.
• W2067477316 hasLocation W20674773161 @default.
• W2067477316 hasLocation W20674773162 @default.
• W2067477316 hasLocation W20674773163 @default.
• W2067477316 hasLocation W20674773164 @default.

• next