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- W2067480143 abstract "A highly practical and efficient preparation of 6-methy-4H-thiochromene and 7-methyl-thiochromene[2,3-d]pyrimidine derivatives was developed via a multi-component reaction of 3-methyl-thiophenol (1), aldehydes (2), and malononitrile (3). A series of pyrimidine nucleoside, thiochromene[2,3-d]pyrimidine and thiochromene[2,3-d]pyrimidine-10-sulfone was efficiently obtained. These hybrid compounds were evaluated as potential antibacterial and anticancer agents and showed encouraging biological activities. Some of these derivatives showed broad-spectrum antitumour activity against the nine tumour subpanels tested, and demonstrated significant activity in the in vitro antitumour screening expressed by MG-MID log10GI50 value of －4.55, －4.67 and －4.73 of compounds 9a, 9b and 9c, respectively." @default.
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- W2067480143 date "2013-01-01" @default.
- W2067480143 modified "2023-09-28" @default.
- W2067480143 title "Efficient Synthesis of a New Class of <i>N</i>-Nucleosides of 4<i>H</i>-Thiochromeno[2,3-<i>d</i>]pyrimidine-10-Sulfone as Potential Anticancer and Antibacterial Agents" @default.
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- W2067480143 doi "https://doi.org/10.4236/ijoc.2013.33a003" @default.
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