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- W2067480515 abstract "1 The effects of d-fenfluramine were studied in the JCR: LA-corpulent rat that is grossly obese, hyperphagic, hyperlipidaemic, hyperinsulinaemic and atherosclerosis-prone. 2 Daily doses of 1, 2.5 and 5 mg kg−1 of d-fenfluramine produced sustained decreases in body weight and food intake over a period of 30 days in 6 month old female rats fed ad libitum. This was accompanied by decreases in the circulating concentrations of glucose, triacylglycerol, free cholesterol and insulin. 3 Food restriction imposed by meal feeding also decreased circulating glucose, triacylglycerols, cholesterol and insulin and diminished the effect of d-fenfluramine on these parameters in male and female rats. 4 Addition of d-fenfluramine to drinking water to give a dose of about 0.25 mg kg−1 daily produced a sustained decrease in body weight and food intake of male and female rats over a nine week period. 5 The results show that the JCR: LA-corpulent rat is very sensitive to the pharmacological effects of d-fenfluramine. These rats should provide an appropriate animal model for determining the mechanisms of action of this antiobesity agent and whether apparently beneficial changes in metabolism translate into long-term protection against premature atherosclerosis." @default.
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- W2067480515 date "1992-03-01" @default.
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- W2067480515 title "Sustained decreases in weight and serum insulin, glucose, triacylglycerol and cholesterol in JCR: LA-corpulent rats treated with d-fenfluramine" @default.
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- W2067480515 doi "https://doi.org/10.1111/j.1476-5381.1992.tb09038.x" @default.
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