Matches in SemOpenAlex for { <https://semopenalex.org/work/W2067492735> ?p ?o ?g. }
- W2067492735 endingPage "2331" @default.
- W2067492735 startingPage "2326" @default.
- W2067492735 abstract "CD40 ligand (CD40L) is a 33-kDa type II membrane glycoprotein induced on T cells upon activation. CD40L has previously been shown to induce proliferation of resting B cells, immunoglobulin (Ig) secretion from B cells cultured with cytokines and cytokine secretion and tumoricidal activity from monocytes. In this report CD40L is shown to be stimulatory for human T cells, inducing CD25 (p55 IL-2R) and CD40L expression on resting peripheral blood T cells, enhanced expression of these molecules and CD69 on CD3-activated cells and secretion of interferon-y, tumor necrosis factor-a and interleukin (IL)-2 from T cells cultured in the presence of a sub-mitogenic concentration of phytohemagglutinin A (PHA). Furthermore, stimulation with CD40L induces proliferation of CD3- or PHA-activated T cells of blood, tonsillar or thymic origin. A similar proliferative response is observed with CD4− and CD8+ T cells and this effect is largely IL-2 independent. A soluble construct of the extracellular domain of the CD40L has similar activity to that of membrane-expressed ligand in the induction of T cell surface antigens and proliferation. The results presented here taken together with the various activities ascribed for CD40L on B cells and monocytes demonstrate that CD40L has pleiotropic biological activity for cells of the hemopoietic lineage." @default.
- W2067492735 created "2016-06-24" @default.
- W2067492735 creator A5018054398 @default.
- W2067492735 creator A5036419266 @default.
- W2067492735 creator A5043390100 @default.
- W2067492735 creator A5050752577 @default.
- W2067492735 creator A5053029595 @default.
- W2067492735 creator A5060338193 @default.
- W2067492735 creator A5073973143 @default.
- W2067492735 date "1993-09-01" @default.
- W2067492735 modified "2023-09-26" @default.
- W2067492735 title "CD40 ligand is a T cell growth factor" @default.
- W2067492735 cites W1506157243 @default.
- W2067492735 cites W1517873264 @default.
- W2067492735 cites W1523575552 @default.
- W2067492735 cites W1528551608 @default.
- W2067492735 cites W1574705898 @default.
- W2067492735 cites W1581150959 @default.
- W2067492735 cites W1592901497 @default.
- W2067492735 cites W1621157891 @default.
- W2067492735 cites W1756135215 @default.
- W2067492735 cites W1919103296 @default.
- W2067492735 cites W1964264035 @default.
- W2067492735 cites W1965979978 @default.
- W2067492735 cites W1969067888 @default.
- W2067492735 cites W1971496886 @default.
- W2067492735 cites W1975538194 @default.
- W2067492735 cites W1975559712 @default.
- W2067492735 cites W1977947625 @default.
- W2067492735 cites W1980793481 @default.
- W2067492735 cites W1987653378 @default.
- W2067492735 cites W1987968095 @default.
- W2067492735 cites W1989055057 @default.
- W2067492735 cites W1989270381 @default.
- W2067492735 cites W1989305940 @default.
- W2067492735 cites W1989692667 @default.
- W2067492735 cites W2000517438 @default.
- W2067492735 cites W2020971843 @default.
- W2067492735 cites W2029249439 @default.
- W2067492735 cites W2035261951 @default.
- W2067492735 cites W2038985770 @default.
- W2067492735 cites W2047800730 @default.
- W2067492735 cites W2049020751 @default.
- W2067492735 cites W2049410931 @default.
- W2067492735 cites W2050432242 @default.
- W2067492735 cites W2057091891 @default.
- W2067492735 cites W2057784785 @default.
- W2067492735 cites W2058050336 @default.
- W2067492735 cites W2060382742 @default.
- W2067492735 cites W2065270456 @default.
- W2067492735 cites W2073777388 @default.
- W2067492735 cites W2079041842 @default.
- W2067492735 cites W2086112868 @default.
- W2067492735 cites W2087973624 @default.
- W2067492735 cites W2088689097 @default.
- W2067492735 cites W2094799089 @default.
- W2067492735 cites W2095672355 @default.
- W2067492735 cites W2102156468 @default.
- W2067492735 cites W2103493503 @default.
- W2067492735 cites W2112276624 @default.
- W2067492735 cites W2131012769 @default.
- W2067492735 cites W2134677648 @default.
- W2067492735 cites W2135252042 @default.
- W2067492735 cites W2147734974 @default.
- W2067492735 cites W2148330408 @default.
- W2067492735 cites W2156213011 @default.
- W2067492735 cites W2162320664 @default.
- W2067492735 cites W2168822788 @default.
- W2067492735 cites W2168894946 @default.
- W2067492735 cites W2170300105 @default.
- W2067492735 doi "https://doi.org/10.1002/eji.1830230941" @default.
- W2067492735 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7690330" @default.
- W2067492735 hasPublicationYear "1993" @default.
- W2067492735 type Work @default.
- W2067492735 sameAs 2067492735 @default.
- W2067492735 citedByCount "115" @default.
- W2067492735 countsByYear W20674927352012 @default.
- W2067492735 countsByYear W20674927352013 @default.
- W2067492735 countsByYear W20674927352014 @default.
- W2067492735 countsByYear W20674927352015 @default.
- W2067492735 countsByYear W20674927352019 @default.
- W2067492735 countsByYear W20674927352023 @default.
- W2067492735 crossrefType "journal-article" @default.
- W2067492735 hasAuthorship W2067492735A5018054398 @default.
- W2067492735 hasAuthorship W2067492735A5036419266 @default.
- W2067492735 hasAuthorship W2067492735A5043390100 @default.
- W2067492735 hasAuthorship W2067492735A5050752577 @default.
- W2067492735 hasAuthorship W2067492735A5053029595 @default.
- W2067492735 hasAuthorship W2067492735A5060338193 @default.
- W2067492735 hasAuthorship W2067492735A5073973143 @default.
- W2067492735 hasConcept C120642132 @default.
- W2067492735 hasConcept C129374314 @default.
- W2067492735 hasConcept C134018914 @default.
- W2067492735 hasConcept C147483822 @default.
- W2067492735 hasConcept C153911025 @default.
- W2067492735 hasConcept C154317977 @default.
- W2067492735 hasConcept C167672396 @default.
- W2067492735 hasConcept C17991360 @default.