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- W2067510355 endingPage "405" @default.
- W2067510355 startingPage "395" @default.
- W2067510355 abstract "Arginase has roots in early life-forms. It converts L-arginine to urea and ornithine. The former provides protection against NH3; the latter serves to stimulate cell growth and other physiological functions. Excessive arginase activity in mammals has been associated with cardiovascular and nervous system dysfunction and disease. Two relevant aspects of this elevated activity may be involved in these disease states. First, excessive arginase activity reduces the supply of L-arginine needed by nitric oxide (NO) synthase to produce NO. Second, excessive production of ornithine leads to vascular structural problems and neural toxicity. Recent research has identified inflammatory agents and reactive oxygen species (ROS) as drivers of this pathologic elevation of arginase activity and expression. We review the involvement of arginase in cardiovascular and nervous system dysfunction, and discuss potential therapeutic interventions targeting excess arginase." @default.
- W2067510355 created "2016-06-24" @default.
- W2067510355 creator A5043125427 @default.
- W2067510355 creator A5057027087 @default.
- W2067510355 creator A5058254450 @default.
- W2067510355 date "2015-06-01" @default.
- W2067510355 modified "2023-10-17" @default.
- W2067510355 title "Arginase: an old enzyme with new tricks" @default.
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