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- W206751921 endingPage "4673" @default.
- W206751921 startingPage "4673" @default.
- W206751921 abstract "Hepatitis B virus protein X (HBx) has been shown to be weakly oncogenic in vitro. The transforming activities of HBx have been linked with the inhibition of several functions of the tumor suppressor p53. We have studied whether HBx may have different effects on p53 depending on the cell type.We used the human hepatoma cell line HepG2 and the immortalized murine hepatocyte line AML12 and analyzed stably transfected clones which expressed physiological amounts of HBx. P53 was induced by UV irradiation.The p53 induction by UV irradiation was unaffected by stable expression of HBx. However, the expression of the cyclin kinase inhibitor p21(waf/cip/sdi) which gets activated by p53 was affected in the HBx transformed cell line AML12-HBx9, but not in HepG2. In AML-HBx9 cells, p21(waf/cip/sdi)-protein expression and p21(waf/cip/sdi) transcription were deregulated. Furthermore, the process of apoptosis was affected in opposite ways in the two cell lines investigated. While stable expression of HBx enhanced apoptosis induced by UV irradiation in HepG2-cells, apoptosis was decreased in HBx transformed AML12-HBx9. P53 repressed transcription from the HBV enhancer I, when expressed from expression vectors or after induction of endogenous p53 by UV irradiation. Repression by endogenous p53 was partially reversible by stably expressed HBx in both cell lines.Stable expression of HBx leads to deregulation of apoptosis induced by UV irradiation depending on the cell line used. In an immortalized hepatocyte line HBx acted anti-apoptotic whereas expression in a carcinoma derived hepatocyte line HBx enhanced apoptosis." @default.
- W206751921 created "2016-06-24" @default.
- W206751921 creator A5018084121 @default.
- W206751921 creator A5019903193 @default.
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- W206751921 creator A5051231892 @default.
- W206751921 creator A5064014455 @default.
- W206751921 creator A5086930683 @default.
- W206751921 date "2006-01-01" @default.
- W206751921 modified "2023-09-26" @default.
- W206751921 title "Differential effects on apoptosis induction in hepatocyte lines by stable expression of hepatitis B virus X protein" @default.
- W206751921 cites W1480852720 @default.
- W206751921 cites W1488842947 @default.
- W206751921 cites W1491403191 @default.
- W206751921 cites W1525178335 @default.
- W206751921 cites W1539896917 @default.
- W206751921 cites W1548529343 @default.
- W206751921 cites W1576500260 @default.
- W206751921 cites W161671135 @default.
- W206751921 cites W1651425720 @default.
- W206751921 cites W1656708631 @default.
- W206751921 cites W1752352308 @default.
- W206751921 cites W1966071985 @default.
- W206751921 cites W1970848975 @default.
- W206751921 cites W1973178656 @default.
- W206751921 cites W1977638924 @default.
- W206751921 cites W1982598173 @default.
- W206751921 cites W1983796564 @default.
- W206751921 cites W1984058368 @default.
- W206751921 cites W1985022589 @default.
- W206751921 cites W1985747524 @default.
- W206751921 cites W1986099727 @default.
- W206751921 cites W1986676942 @default.
- W206751921 cites W1986937860 @default.
- W206751921 cites W1987536971 @default.
- W206751921 cites W1988756673 @default.
- W206751921 cites W1992667313 @default.
- W206751921 cites W1993384459 @default.
- W206751921 cites W1994018922 @default.
- W206751921 cites W1995289527 @default.
- W206751921 cites W1995743278 @default.
- W206751921 cites W1998551192 @default.
- W206751921 cites W1999609085 @default.
- W206751921 cites W2003459252 @default.
- W206751921 cites W2005383067 @default.
- W206751921 cites W2005790594 @default.
- W206751921 cites W2007772649 @default.
- W206751921 cites W2007935491 @default.
- W206751921 cites W2011257176 @default.
- W206751921 cites W2011607753 @default.
- W206751921 cites W2012053348 @default.
- W206751921 cites W2015464799 @default.
- W206751921 cites W2015519364 @default.
- W206751921 cites W2016876202 @default.
- W206751921 cites W2031079263 @default.
- W206751921 cites W2031841760 @default.
- W206751921 cites W2032781689 @default.
- W206751921 cites W2034296773 @default.
- W206751921 cites W2034909046 @default.
- W206751921 cites W2035312783 @default.
- W206751921 cites W2049344329 @default.
- W206751921 cites W2050274505 @default.
- W206751921 cites W2056570769 @default.
- W206751921 cites W2058349670 @default.
- W206751921 cites W2064554826 @default.
- W206751921 cites W2064645067 @default.
- W206751921 cites W2067279573 @default.
- W206751921 cites W2067692139 @default.
- W206751921 cites W2068691401 @default.
- W206751921 cites W2069781517 @default.
- W206751921 cites W2071985423 @default.
- W206751921 cites W2073296716 @default.
- W206751921 cites W2076676971 @default.
- W206751921 cites W2076685716 @default.
- W206751921 cites W2076982594 @default.
- W206751921 cites W2077311317 @default.
- W206751921 cites W2077675724 @default.
- W206751921 cites W2079673516 @default.
- W206751921 cites W2082465255 @default.
- W206751921 cites W2083627679 @default.
- W206751921 cites W2084725999 @default.
- W206751921 cites W2085323757 @default.
- W206751921 cites W2112674459 @default.
- W206751921 cites W2116810304 @default.
- W206751921 cites W2117484925 @default.
- W206751921 cites W2125595732 @default.
- W206751921 cites W2128366838 @default.
- W206751921 cites W2129905922 @default.
- W206751921 cites W2134748677 @default.
- W206751921 cites W2147842298 @default.
- W206751921 cites W2149175860 @default.
- W206751921 cites W2152175101 @default.
- W206751921 cites W2154226166 @default.
- W206751921 cites W2156922255 @default.
- W206751921 cites W2160567170 @default.
- W206751921 cites W2160740567 @default.
- W206751921 cites W2162421166 @default.