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- W2067523040 abstract "The mechanisms by which presynaptic neurones differentially regulate synaptic transmission with multiple postsynaptic targets in the brain are not fully understood. Using intracellular sharp electrode and whole-cell voltage-clamp recordings of soma-soma synapses between identified Lymnaea neurones, we provide direct evidence that quantal size is regulated presynaptically through the coupling of multiple release sites. This coupling effectively multiplies quantal size, thereby providing significant influence over parameters of synaptic transmission that are influenced by quantal size, such as the variance in transmitter release at stationary release probabilities. Variation in the degree of coupling is dependent on the identity of the postsynaptic cell, even though the variation in quantal size is of presynaptic origin. We have therefore demonstrated the presence of a novel mechanism by which presynaptic neurones may differentially regulate quantal size at select synaptic connections, in turn providing them with a means of regulating synaptic transmission with multiple postsynaptic cells." @default.
- W2067523040 created "2016-06-24" @default.
- W2067523040 creator A5043678788 @default.
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- W2067523040 date "2006-09-01" @default.
- W2067523040 modified "2023-10-10" @default.
- W2067523040 title "Ryanodine receptor-transmitter release site coupling increases quantal size in a synapse-specific manner" @default.
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- W2067523040 doi "https://doi.org/10.1111/j.1460-9568.2006.05028.x" @default.
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