FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2067532353> ?p ?o ?g. }

• W2067532353 endingPage "150" @default.
• W2067532353 startingPage "140" @default.
• W2067532353 abstract "Metallothioneins (MT) are heavy metal-binding, antioxidant proteins with relevant roles described in many pathological conditions affecting the central nervous system (CNS). Regarding prion diseases, a number of publications demonstrate an up-regulation of MT-1+2 in the brains of TSE affected cattle, humans and experimentally inoculated rodents. Since the prion protein also binds copper, and oxidative stress is one of the events presumably triggered by PrPsc deposition, it seems plausible that MTs have a relevant role in the outcome of these neurodegenerative processes. To gain knowledge of the role of MTs in TSE pathogeny, and particularly of that of MT-1+2, a transgenic MT-1+2 knockout mouse model (MT-1+2 KO) was intracerebrally inoculated with the mouse-adapted Rocky Mountain Laboratory (RML) strain of scrapie; 129SvJ mice were used as controls (WT). Clinical signs were monitored and animals were humanely sacrificed when they scored positive clinically. Brains were fixed following intracardiac perfusion with 4% formaldehyde, paraffin embedded, and processed for histological, histochemical and immunohistochemical evaluation. The incubation period did not show significant differences between MT-1+2 KO and WT mice, nor did the evolution of neurological signs. Upon neuropathological characterisation of the brains, moderate differences were observed in astroglial and microglial response, spongiosis score and PrPsc deposition, particularly in brain regions to which the studied strain showed a stronger tropism (i.e. hippocampus). Results showed that the brain defence mechanisms against PrPsc deposition involve, aside from MT-1+2, other molecules, such as HSP25, which are capable of compensating for the lack of MT-1+2." @default.
• W2067532353 created "2016-06-24" @default.
• W2067532353 creator A5010168694 @default.
• W2067532353 creator A5030113409 @default.
• W2067532353 creator A5038158528 @default.
• W2067532353 creator A5065336841 @default.
• W2067532353 creator A5084924807 @default.
• W2067532353 creator A5087981467 @default.
• W2067532353 date "2008-02-01" @default.
• W2067532353 modified "2023-09-27" @default.
• W2067532353 title "Infection of metallothionein 1+2 knockout mice with Rocky Mountain Laboratory scrapie" @default.
• W2067532353 cites W1483204127 @default.
• W2067532353 cites W149247114 @default.
• W2067532353 cites W1537274817 @default.
• W2067532353 cites W1567272218 @default.
• W2067532353 cites W1575128625 @default.
• W2067532353 cites W1683598352 @default.
• W2067532353 cites W1968815246 @default.
• W2067532353 cites W1974443289 @default.
• W2067532353 cites W1976038427 @default.
• W2067532353 cites W1982013273 @default.
• W2067532353 cites W1986832899 @default.
• W2067532353 cites W1987043897 @default.
• W2067532353 cites W1990139471 @default.
• W2067532353 cites W1992256486 @default.
• W2067532353 cites W1993242675 @default.
• W2067532353 cites W1995802493 @default.
• W2067532353 cites W2000543953 @default.
• W2067532353 cites W2000867734 @default.
• W2067532353 cites W2001656142 @default.
• W2067532353 cites W2004731363 @default.
• W2067532353 cites W2007128111 @default.
• W2067532353 cites W2008343355 @default.
• W2067532353 cites W2014099339 @default.
• W2067532353 cites W2014626240 @default.
• W2067532353 cites W2019301423 @default.
• W2067532353 cites W2026534774 @default.
• W2067532353 cites W2029133386 @default.
• W2067532353 cites W2030397711 @default.
• W2067532353 cites W2037813697 @default.
• W2067532353 cites W2038142091 @default.
• W2067532353 cites W2039486260 @default.
• W2067532353 cites W2044315549 @default.
• W2067532353 cites W2045865115 @default.
• W2067532353 cites W2056914045 @default.
• W2067532353 cites W2058069757 @default.
• W2067532353 cites W2061822084 @default.
• W2067532353 cites W2062354055 @default.
• W2067532353 cites W2063950202 @default.
• W2067532353 cites W2065350866 @default.
• W2067532353 cites W2067264815 @default.
• W2067532353 cites W2068482929 @default.
• W2067532353 cites W2069104469 @default.
• W2067532353 cites W2072048800 @default.
• W2067532353 cites W2088628671 @default.
• W2067532353 cites W2088664861 @default.
• W2067532353 cites W2089701069 @default.
• W2067532353 cites W2092306608 @default.
• W2067532353 cites W2097029336 @default.
• W2067532353 cites W2099956125 @default.
• W2067532353 cites W2110484308 @default.
• W2067532353 cites W2133766206 @default.
• W2067532353 cites W2136197942 @default.
• W2067532353 cites W2137241623 @default.
• W2067532353 cites W2143609309 @default.
• W2067532353 cites W2150554290 @default.
• W2067532353 cites W2153477671 @default.
• W2067532353 cites W2164123708 @default.
• W2067532353 cites W2171362178 @default.
• W2067532353 doi "https://doi.org/10.1016/j.brainres.2007.12.034" @default.
• W2067532353 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18221736" @default.
• W2067532353 hasPublicationYear "2008" @default.
• W2067532353 type Work @default.
• W2067532353 sameAs 2067532353 @default.
• W2067532353 citedByCount "9" @default.
• W2067532353 countsByYear W20675323532014 @default.
• W2067532353 countsByYear W20675323532016 @default.
• W2067532353 countsByYear W20675323532020 @default.
• W2067532353 crossrefType "journal-article" @default.
• W2067532353 hasAuthorship W2067532353A5010168694 @default.
• W2067532353 hasAuthorship W2067532353A5030113409 @default.
• W2067532353 hasAuthorship W2067532353A5038158528 @default.
• W2067532353 hasAuthorship W2067532353A5065336841 @default.
• W2067532353 hasAuthorship W2067532353A5084924807 @default.
• W2067532353 hasAuthorship W2067532353A5087981467 @default.
• W2067532353 hasConcept C102230213 @default.
• W2067532353 hasConcept C104317684 @default.
• W2067532353 hasConcept C134018914 @default.
• W2067532353 hasConcept C141035611 @default.
• W2067532353 hasConcept C142724271 @default.
• W2067532353 hasConcept C169760540 @default.
• W2067532353 hasConcept C170493617 @default.
• W2067532353 hasConcept C182704531 @default.
• W2067532353 hasConcept C203014093 @default.
• W2067532353 hasConcept C204232928 @default.
• W2067532353 hasConcept C20719415 @default.
• W2067532353 hasConcept C2776151105 @default.
• W2067532353 hasConcept C2776735649 @default.

• next