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- W2067556304 abstract "A study was made of the differences in tumor growth and their relationship to tumor blood flow in several different tissues. A suspension of V2 carcinoma cells was implanted in the liver, spleen, kidney, testicle and ear of 34 New Zealand white rabbits. Two weeks after implantation, V2 carcinoma and surrounding normal host tissue blood flow was determined with radioactive microspheres. Total tumor weight was found to be related to the site of implantation: liver (8.7 g), spleen (8.4 g), kidney (2.9 g), testicle (1.2 g) and ear (0.4 g). The amount of gross caseous necrosis in the V2 carcinoma was also related to implantation site. The organ with the largest proportion of grossly non-necrotic tumor was the liver (5% necrotic) and that with the least was the spleen (62% necrotic). V2 blood flow also varied with implantation site, the highest being found in the kidney (1.3 ml/g/min) and the lowest in the ear (0.14 ml/g/min). Regression analysis revealed that tumor blood flow was directly related to resting blood flow in the surrounding host parenchyma. However, no relationship existed between tumor perfusion and either tumor size or the amount of central necrosis." @default.
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- W2067556304 date "1979-05-01" @default.
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- W2067556304 title "The influence of implantation site on tumor growth and blood flow" @default.
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- W2067556304 doi "https://doi.org/10.1016/0014-2964(79)90152-x" @default.
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