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- W2067562016 abstract "Plasma or whole venous or arterialized blood from healthy human donors was incubated with NO (50–300 μ m ), and the resulting formation of methaemoglobin (MetHb), nitrosyl haemoglobin (HbNO), and plasma nitrite and nitrate were measured. In plasma, NO was converted to nitrite and nitrate in a ratio of 5:1. In arterial blood (O 2 sat. 94–99%) NO was almost quantitatively converted to nitrate and MetHb. No nitrite was detected and HbNO formation was low. In venous blood (O 2 sat. 36–85%) more HbNO and less nitrate was formed, in comparison to arterialized blood. We propose that NO liberated from endothelium of conductance and resistance vessels is taken up by red blood cells and inactivated by HbO 2 via stoichiometric conversion to MetHb and nitrate." @default.
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- W2067562016 date "1992-07-01" @default.
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- W2067562016 title "Dependence of the metabolism of nitric oxide (NO) in healthy human whole blood on the oxygenation of its red cell haemoglobin" @default.
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- W2067562016 doi "https://doi.org/10.1111/j.1476-5381.1992.tb14365.x" @default.
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