Matches in SemOpenAlex for { <https://semopenalex.org/work/W2067567223> ?p ?o ?g. }
- W2067567223 abstract "Thiopental is an anesthetic used for controlling high intracranial pressure (ICP) caused by brain surgery, brain trauma, and severe stroke. However, it remains controversial whether Thiopental is detrimental or beneficial in ischemic stroke. In this study, we used an animal model of ischemic stroke in spontaneously hypertensive rats to determine whether or not Thiopental is neuroprotective in the setting of brain ischemia. We observed that Thiopental caused a prolonged duration of unconsciousness with a high rate of mortality, that Thiopental created exaggerated neurological deficits that were revealed through limb placement tests at 4 days and 4 weeks after brain ischemia, and that infarct volume was increased in Thiopental-anesthetized rats. These data suggest that Thiopental is detrimental in ischemic stroke. Thus, our findings raise a caution about the use of Thiopental in the setting of ischemic stroke." @default.
- W2067567223 created "2016-06-24" @default.
- W2067567223 creator A5004577784 @default.
- W2067567223 creator A5049275369 @default.
- W2067567223 creator A5067890554 @default.
- W2067567223 creator A5079752398 @default.
- W2067567223 creator A5091482274 @default.
- W2067567223 date "2009-10-01" @default.
- W2067567223 modified "2023-09-25" @default.
- W2067567223 title "Thiopental exaggerates ischemic brain damage and neurological deficits after experimental stroke in spontaneously hypertensive rats" @default.
- W2067567223 cites W156565107 @default.
- W2067567223 cites W1968532657 @default.
- W2067567223 cites W1970738472 @default.
- W2067567223 cites W1970742138 @default.
- W2067567223 cites W1972737397 @default.
- W2067567223 cites W1979299324 @default.
- W2067567223 cites W1988086690 @default.
- W2067567223 cites W1989014567 @default.
- W2067567223 cites W2003240030 @default.
- W2067567223 cites W2006571779 @default.
- W2067567223 cites W2011394277 @default.
- W2067567223 cites W2019541577 @default.
- W2067567223 cites W2020114172 @default.
- W2067567223 cites W2021370073 @default.
- W2067567223 cites W2022514762 @default.
- W2067567223 cites W2027696124 @default.
- W2067567223 cites W2028265130 @default.
- W2067567223 cites W2032308540 @default.
- W2067567223 cites W2037159781 @default.
- W2067567223 cites W2049161368 @default.
- W2067567223 cites W2056344187 @default.
- W2067567223 cites W2060766725 @default.
- W2067567223 cites W2063284631 @default.
- W2067567223 cites W2065498565 @default.
- W2067567223 cites W2073717839 @default.
- W2067567223 cites W2091789499 @default.
- W2067567223 cites W2094139788 @default.
- W2067567223 cites W2099706007 @default.
- W2067567223 cites W2111361014 @default.
- W2067567223 cites W2131150967 @default.
- W2067567223 cites W2133934898 @default.
- W2067567223 cites W2136414262 @default.
- W2067567223 cites W2142880742 @default.
- W2067567223 cites W2145838860 @default.
- W2067567223 cites W2148503090 @default.
- W2067567223 cites W2161757080 @default.
- W2067567223 cites W2169160949 @default.
- W2067567223 cites W2171881869 @default.
- W2067567223 cites W2310313759 @default.
- W2067567223 cites W2318833383 @default.
- W2067567223 cites W44493068 @default.
- W2067567223 cites W2409580120 @default.
- W2067567223 cites W2464005135 @default.
- W2067567223 doi "https://doi.org/10.1016/j.brainres.2009.07.080" @default.
- W2067567223 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19646967" @default.
- W2067567223 hasPublicationYear "2009" @default.
- W2067567223 type Work @default.
- W2067567223 sameAs 2067567223 @default.
- W2067567223 citedByCount "4" @default.
- W2067567223 countsByYear W20675672232014 @default.
- W2067567223 countsByYear W20675672232015 @default.
- W2067567223 countsByYear W20675672232018 @default.
- W2067567223 countsByYear W20675672232019 @default.
- W2067567223 crossrefType "journal-article" @default.
- W2067567223 hasAuthorship W2067567223A5004577784 @default.
- W2067567223 hasAuthorship W2067567223A5049275369 @default.
- W2067567223 hasAuthorship W2067567223A5067890554 @default.
- W2067567223 hasAuthorship W2067567223A5079752398 @default.
- W2067567223 hasAuthorship W2067567223A5091482274 @default.
- W2067567223 hasConcept C126322002 @default.
- W2067567223 hasConcept C127413603 @default.
- W2067567223 hasConcept C164705383 @default.
- W2067567223 hasConcept C25498285 @default.
- W2067567223 hasConcept C2776277131 @default.
- W2067567223 hasConcept C2776470351 @default.
- W2067567223 hasConcept C2778820722 @default.
- W2067567223 hasConcept C2780645631 @default.
- W2067567223 hasConcept C2910962159 @default.
- W2067567223 hasConcept C42219234 @default.
- W2067567223 hasConcept C541997718 @default.
- W2067567223 hasConcept C71924100 @default.
- W2067567223 hasConcept C78519656 @default.
- W2067567223 hasConceptScore W2067567223C126322002 @default.
- W2067567223 hasConceptScore W2067567223C127413603 @default.
- W2067567223 hasConceptScore W2067567223C164705383 @default.
- W2067567223 hasConceptScore W2067567223C25498285 @default.
- W2067567223 hasConceptScore W2067567223C2776277131 @default.
- W2067567223 hasConceptScore W2067567223C2776470351 @default.
- W2067567223 hasConceptScore W2067567223C2778820722 @default.
- W2067567223 hasConceptScore W2067567223C2780645631 @default.
- W2067567223 hasConceptScore W2067567223C2910962159 @default.
- W2067567223 hasConceptScore W2067567223C42219234 @default.
- W2067567223 hasConceptScore W2067567223C541997718 @default.
- W2067567223 hasConceptScore W2067567223C71924100 @default.
- W2067567223 hasConceptScore W2067567223C78519656 @default.
- W2067567223 hasLocation W20675672231 @default.
- W2067567223 hasLocation W20675672232 @default.
- W2067567223 hasOpenAccess W2067567223 @default.
- W2067567223 hasPrimaryLocation W20675672231 @default.
- W2067567223 hasRelatedWork W1973917792 @default.