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• W2067579040 abstract "The aim of this study was to use optical imaging with voltage-sensitive dyes (Di-4-ANEPPS), to examine the cholinergic modulation of CA1 network responses to Schaffer collateral input. By comparing responses recorded with optical imaging and field recordings across the proximodistal axis of CA1, it was initially demonstrated that voltage-sensitive dyes could report reliably both the pattern of activation and cholinergic modulation. The higher spatial resolution of optical imaging was used to explore the somatodendritic profile of cholinergic modulation. It was found that activation of muscarinic acetylcholine receptors (mAChR) (1–10 μM carbachol), inhibited evoked responses across all layers of CA1. This was accompanied by an increase in paired-pulse facilitation in the apical and distal dendritic layers (40 ms inter-stimulus interval), but not in perisomatic regions. The mAChR antagonist, 20 μM atropine, alone increased facilitation at perisomatic sites, suggesting that muscarinic signalling pathways actively suppress perisomatic responses to repetitive stimulation. In contrast, the activation of nicotinic acetylcholine receptors (10 μM nicotine) had no significant effect on single evoked responses, but selectively increased facilitation at perisomatic sites. These results suggest that cholinergic modulation of the hippocampal CA1 network has multiple differential effects on the somatodendritic processing of the Schaffer collateral input." @default.
• W2067579040 created "2016-06-24" @default.
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• W2067579040 date "2005-01-01" @default.
• W2067579040 modified "2023-10-10" @default.
• W2067579040 title "Cholinergic modulation of the spatiotemporal pattern of hippocampal activity in vitro" @default.
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• W2067579040 doi "https://doi.org/10.1016/j.neuropharm.2004.08.022" @default.
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