FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2067582627> ?p ?o ?g. }

• W2067582627 endingPage "593" @default.
• W2067582627 startingPage "582" @default.
• W2067582627 abstract "There is an urgent need for preclinical translational efforts to be realized as breakthroughs in therapy for the many patients with life-altering conditions affecting the CNS. Despite intensive efforts, few transformative therapies have emerged, and many new potential therapies that looked promising in preclinical development have failed in the clinic. In this Perspective, we suggest that if preclinical scientists partner early with clinical scientists, they can begin to envision the pathway forward for their work through clinical trials. Options might include determining the populations to be treated, issues of dose selection, timing of intervention, duration of intervention, and the availability of biomarkers. In addition, understanding other factors that impact the likelihood that a proof-of-concept trial can be performed, as well as other critical issues, will altogether increase the attractiveness of the project to investors and partners and will also increase the likelihood that the intervention will succeed in the clinic. There is an urgent need for preclinical translational efforts to be realized as breakthroughs in therapy for the many patients with life-altering conditions affecting the CNS. Despite intensive efforts, few transformative therapies have emerged, and many new potential therapies that looked promising in preclinical development have failed in the clinic. In this Perspective, we suggest that if preclinical scientists partner early with clinical scientists, they can begin to envision the pathway forward for their work through clinical trials. Options might include determining the populations to be treated, issues of dose selection, timing of intervention, duration of intervention, and the availability of biomarkers. In addition, understanding other factors that impact the likelihood that a proof-of-concept trial can be performed, as well as other critical issues, will altogether increase the attractiveness of the project to investors and partners and will also increase the likelihood that the intervention will succeed in the clinic." @default.
• W2067582627 created "2016-06-24" @default.
• W2067582627 creator A5005402221 @default.
• W2067582627 creator A5038885649 @default.
• W2067582627 creator A5071565453 @default.
• W2067582627 creator A5088706930 @default.
• W2067582627 date "2014-11-01" @default.
• W2067582627 modified "2023-10-17" @default.
• W2067582627 title "How Clinical Development Can, and Should, Inform Translational Science" @default.
• W2067582627 cites W146612229 @default.
• W2067582627 cites W1509487329 @default.
• W2067582627 cites W1591584201 @default.
• W2067582627 cites W1880320779 @default.
• W2067582627 cites W1914647369 @default.
• W2067582627 cites W1964600153 @default.
• W2067582627 cites W1964991931 @default.
• W2067582627 cites W1969055995 @default.
• W2067582627 cites W1973791723 @default.
• W2067582627 cites W1973852637 @default.
• W2067582627 cites W1977830444 @default.
• W2067582627 cites W1979790577 @default.
• W2067582627 cites W1987864204 @default.
• W2067582627 cites W1988545157 @default.
• W2067582627 cites W1992294123 @default.
• W2067582627 cites W1996286939 @default.
• W2067582627 cites W2000567608 @default.
• W2067582627 cites W2003312366 @default.
• W2067582627 cites W2004834960 @default.
• W2067582627 cites W2005627616 @default.
• W2067582627 cites W2007557482 @default.
• W2067582627 cites W2015484447 @default.
• W2067582627 cites W2017398416 @default.
• W2067582627 cites W2019178697 @default.
• W2067582627 cites W2019304821 @default.
• W2067582627 cites W2020502278 @default.
• W2067582627 cites W2022919161 @default.
• W2067582627 cites W2023205599 @default.
• W2067582627 cites W2025467584 @default.
• W2067582627 cites W2029500295 @default.
• W2067582627 cites W2029774593 @default.
• W2067582627 cites W2031700674 @default.
• W2067582627 cites W2035744498 @default.
• W2067582627 cites W2037673105 @default.
• W2067582627 cites W2047614643 @default.
• W2067582627 cites W2054107031 @default.
• W2067582627 cites W2074074558 @default.
• W2067582627 cites W2076461577 @default.
• W2067582627 cites W2079860596 @default.
• W2067582627 cites W2080119425 @default.
• W2067582627 cites W2080274663 @default.
• W2067582627 cites W2080763041 @default.
• W2067582627 cites W2080818144 @default.
• W2067582627 cites W2087254035 @default.
• W2067582627 cites W2088199839 @default.
• W2067582627 cites W2089791879 @default.
• W2067582627 cites W2091661674 @default.
• W2067582627 cites W2094248714 @default.
• W2067582627 cites W2097281218 @default.
• W2067582627 cites W2098957847 @default.
• W2067582627 cites W2100283245 @default.
• W2067582627 cites W2104209550 @default.
• W2067582627 cites W2111149452 @default.
• W2067582627 cites W2116115819 @default.
• W2067582627 cites W2119103230 @default.
• W2067582627 cites W2119396369 @default.
• W2067582627 cites W2126223811 @default.
• W2067582627 cites W2133072585 @default.
• W2067582627 cites W2135285893 @default.
• W2067582627 cites W2138513371 @default.
• W2067582627 cites W2144536780 @default.
• W2067582627 cites W2151693585 @default.
• W2067582627 cites W2156936624 @default.
• W2067582627 cites W2157185056 @default.
• W2067582627 cites W2160213399 @default.
• W2067582627 cites W2160223635 @default.
• W2067582627 cites W2162157095 @default.
• W2067582627 cites W2163462607 @default.
• W2067582627 cites W2169473035 @default.
• W2067582627 cites W2170813091 @default.
• W2067582627 cites W2247997571 @default.
• W2067582627 cites W2316055407 @default.
• W2067582627 cites W2326912412 @default.
• W2067582627 cites W2689267561 @default.
• W2067582627 cites W2779910084 @default.
• W2067582627 cites W4236081774 @default.
• W2067582627 doi "https://doi.org/10.1016/j.neuron.2014.10.029" @default.
• W2067582627 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25442937" @default.
• W2067582627 hasPublicationYear "2014" @default.
• W2067582627 type Work @default.
• W2067582627 sameAs 2067582627 @default.
• W2067582627 citedByCount "20" @default.
• W2067582627 countsByYear W20675826272015 @default.
• W2067582627 countsByYear W20675826272016 @default.
• W2067582627 countsByYear W20675826272017 @default.
• W2067582627 countsByYear W20675826272018 @default.
• W2067582627 countsByYear W20675826272019 @default.
• W2067582627 countsByYear W20675826272020 @default.
• W2067582627 countsByYear W20675826272021 @default.

• next