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• W2067600457 abstract "Over the last decade, compelling evidence has linked the development of Alzheimer's disease (AD) to defective intracellular trafficking of the amyloid precursor protein (APP). Faulty APP trafficking results in an overproduction of Aβ peptides, which is generally agreed to be the primary cause of AD-related pathogenesis. LR11 (SorLA), a type I transmembrane sorting receptor, has emerged as a key regulator of APP trafficking and processing. It directly interacts with APP and diverts it away from amyloidogenic processing. The 54-residue cytosolic domain of LR11 is essential for its proper intracellular localization and trafficking which, in turn, determines the fate of APP. Here, we have found a surprising membrane-proximal amphipathic helix in the cytosolic domain of LR11. Moreover, a peptide corresponding to this region folds into an α-helical structure in the presence of liposomes and transforms liposomes to small vesicles and tubule-like particles. We postulate that this amphipathic helix may contribute to the dynamic remodeling of membrane structure and facilitate LR11 intracellular transport. This article is part of a Special Issue entitled: NMR Spectroscopy for Atomistic Views of Biomembranes and Cell Surfaces. Guest Editors: Lynette Cegelski and David P.Weliky." @default.
• W2067600457 created "2016-06-24" @default.
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• W2067600457 creator A5067044507 @default.
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• W2067600457 date "2015-01-01" @default.
• W2067600457 modified "2023-09-27" @default.
• W2067600457 title "A membrane proximal helix in the cytosolic domain of the human APP interacting protein LR11/SorLA deforms liposomes" @default.
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• W2067600457 doi "https://doi.org/10.1016/j.bbamem.2014.05.020" @default.
• W2067600457 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4242801" @default.
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• W2067600457 hasPublicationYear "2015" @default.
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