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- W2067609140 endingPage "128" @default.
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- W2067609140 abstract "Inflammatory regulators, including endogenous anti-inflammatory systems, can down-regulate inflammation thus providing negative feedback. Chronic inflammation can result from imbalance between levels of inflammatory mediators and regulators during immune responses. As a consequence, there are heightened inflammatory responses and irreversible tissue damage associated with many age-related chronic diseases. Alzheimer's disease (AD) brain is marked by prominent inflammatory features, in which microglial activation is the driving force for the elaboration of an inflammatory cascade. How the regulation of inflammation loses its effectiveness during AD pathogenesis remains largely unclear. In this article, we will first review current knowledge of microglial activation and its association with AD pathology. We then discuss four examples of anti-inflammatory systems that could play a role in regulating microglial activation: CD200/CD200 receptor, vitamin D receptor, peroxisome proliferator-activated receptors, and soluble receptor for advanced glycation end products. Through this, we hope to illustrate the diverse aspects of inflammatory regulatory systems in brain and neurodegenerative diseases such as AD. We also propose the importance of neuronal defense systems, because they are part of the integral inflammatory and anti-inflammatory systems. Augmenting the anti-inflammatory defenses of neurons can be included in the strategy for restoration of balanced immune responses during aging and neurodegenerative diseases." @default.
- W2067609140 created "2016-06-24" @default.
- W2067609140 creator A5058815309 @default.
- W2067609140 creator A5059245617 @default.
- W2067609140 creator A5072613176 @default.
- W2067609140 creator A5082708092 @default.
- W2067609140 date "2010-03-03" @default.
- W2067609140 modified "2023-10-14" @default.
- W2067609140 title "Microglia Activation and Anti-inflammatory Regulation in Alzheimer’s Disease" @default.
- W2067609140 cites W1207740807 @default.
- W2067609140 cites W1500603097 @default.
- W2067609140 cites W1503511302 @default.
- W2067609140 cites W1517902812 @default.
- W2067609140 cites W1528113046 @default.
- W2067609140 cites W1562902980 @default.
- W2067609140 cites W1567490604 @default.
- W2067609140 cites W1575263086 @default.
- W2067609140 cites W1598703170 @default.
- W2067609140 cites W1633340712 @default.
- W2067609140 cites W1639924204 @default.
- W2067609140 cites W1663317712 @default.
- W2067609140 cites W1678111194 @default.
- W2067609140 cites W1823419340 @default.
- W2067609140 cites W1836411230 @default.
- W2067609140 cites W1878700164 @default.
- W2067609140 cites W1964041350 @default.
- W2067609140 cites W1964219940 @default.
- W2067609140 cites W1965925370 @default.
- W2067609140 cites W1966510897 @default.
- W2067609140 cites W1967559826 @default.
- W2067609140 cites W1968986793 @default.
- W2067609140 cites W1969932412 @default.
- W2067609140 cites W1970739057 @default.
- W2067609140 cites W1971177781 @default.
- W2067609140 cites W1974077164 @default.
- W2067609140 cites W1976702427 @default.
- W2067609140 cites W1978902831 @default.
- W2067609140 cites W1979413998 @default.
- W2067609140 cites W1983872994 @default.
- W2067609140 cites W1985579937 @default.
- W2067609140 cites W1990636293 @default.
- W2067609140 cites W1993305977 @default.
- W2067609140 cites W1993748281 @default.
- W2067609140 cites W1994885883 @default.
- W2067609140 cites W1999494818 @default.
- W2067609140 cites W2003108859 @default.
- W2067609140 cites W2004837900 @default.
- W2067609140 cites W2007015338 @default.
- W2067609140 cites W2007197518 @default.
- W2067609140 cites W2007771347 @default.
- W2067609140 cites W2011239875 @default.
- W2067609140 cites W2015903618 @default.
- W2067609140 cites W2018708829 @default.
- W2067609140 cites W2022222956 @default.
- W2067609140 cites W2027041567 @default.
- W2067609140 cites W2028989796 @default.
- W2067609140 cites W2029177106 @default.
- W2067609140 cites W2031392840 @default.
- W2067609140 cites W2032288122 @default.
- W2067609140 cites W2036409697 @default.
- W2067609140 cites W2038438278 @default.
- W2067609140 cites W2038604581 @default.
- W2067609140 cites W2040239818 @default.
- W2067609140 cites W2040641201 @default.
- W2067609140 cites W2041851050 @default.
- W2067609140 cites W2044488773 @default.
- W2067609140 cites W2044788039 @default.
- W2067609140 cites W2045940768 @default.
- W2067609140 cites W2047081723 @default.
- W2067609140 cites W2047591801 @default.
- W2067609140 cites W2047964142 @default.
- W2067609140 cites W2049167261 @default.
- W2067609140 cites W2050697792 @default.
- W2067609140 cites W2054398110 @default.
- W2067609140 cites W2059030487 @default.
- W2067609140 cites W2059098049 @default.
- W2067609140 cites W2059844545 @default.
- W2067609140 cites W2060274086 @default.
- W2067609140 cites W2061293090 @default.
- W2067609140 cites W2061941265 @default.
- W2067609140 cites W2063236931 @default.
- W2067609140 cites W2064119008 @default.
- W2067609140 cites W2066331356 @default.
- W2067609140 cites W2070943527 @default.
- W2067609140 cites W2072210142 @default.
- W2067609140 cites W2073440628 @default.
- W2067609140 cites W2074287771 @default.
- W2067609140 cites W2076260194 @default.
- W2067609140 cites W2077133844 @default.
- W2067609140 cites W2077950731 @default.
- W2067609140 cites W2078514181 @default.
- W2067609140 cites W2081080245 @default.
- W2067609140 cites W2082402714 @default.
- W2067609140 cites W2087279936 @default.
- W2067609140 cites W2088642279 @default.
- W2067609140 cites W2088719066 @default.
- W2067609140 cites W2088721908 @default.
- W2067609140 cites W2089388083 @default.