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• W2067609146 abstract "Here we report the isolation of a cDNA encoding the complete human rab18 protein from histamine-stimulated endothelial cells using differential display. The amino acid sequence showed 98% homology with the previously isolated mouse rab18 protein, which is implicated in apical/basolateral endocytosis. Northern blot analysis revealed two transcripts (2.5 kb and 1 kb) ubiquitously expressed in all examined organs, as well as in human umbilical vein endothelial and aortic cells. In blood cells rab18 transcripts were hardly detectable. The histamine-induced time-dependent increase of rab18 mRNA expression in human umbilical vein endothelial cells and peripheral blood mononuclear cells indicates for the first time a link between receptor-mediated signal transduction and the regulation of rab gene expression. This finding might also imply a role for rab proteins in inflammation." @default.
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• W2067609146 date "2000-01-18" @default.
• W2067609146 modified "2023-09-28" @default.
• W2067609146 title "Isolation and characterisation of the human rab18 gene after stimulation of endothelial cells with histamine" @default.
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• W2067609146 doi "https://doi.org/10.1016/s0014-5793(99)01778-0" @default.
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